Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities  

作　　者：Jiu-Da Zhao Pai-Li Geng Zhan-Quan Li Sen Cui Jun-Hui Zhao Li-Juan Wang Jin-Zhang Li Fa-Xiang Ji Guo-Yuan Li Guo-Shuang Shen Ming-Zhe Lin Cun-Fang Shen Cheng-Zhu Cao 

机构地区：[1]Internal Medicine-Oncology,Affiliated Hospital of Qinghai University [2]High Altitude Medical Research Center,Qinghai University

出　　处：《World Journal of Gastroenterology》2012年第47期7093-7099,共7页世界胃肠病学杂志（英文版）

基　　金：Supported by Grants from the National Natural Science Foun dation of China,No.30860259;the Youth Scientific Re search Foundation of Qinghai University,No.2008-QY-09

摘　　要：AIM:To investigate the associations between interleukin(IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet,Hui and Han ethnicities.METHODS:Genomic DNA was extracted from peripheral blood of 210,205,and 202 healthy volunteers and from 155,158,and 197 gastric cancer patients from the Tibet,Hui,and Han populations,respectively.Polymorphisms in IL-1B and IL-1RN were analyzed by denaturing high-performance liquid chromatography.RESULTS:Carriers of the IL-1B-31 CC genotype had an increased risk of intestinal type gastric cancer [odds ratio(OR) = 2.17,P = 0.037] in the Tibet ethnicity.Carriers of the IL-1B 2/L genotype had an increased risk of both intestinal and diffuse types of gastric cancer(OR = 2.08,2.31,P = 0.007,0.016,respectively) in the Hui ethnicity.In the Han population,carriers of the IL-1B-31 CC,IL-1B-511CT,TT genotypes had increased risk of intestinal type gastric cancer(OR = 2.51,2.74,5.66,P = 0.005,0.002,0.000,respectively).CONCLUSION:IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet,Hui,and Han ethnicities in the Qinghai area of China.AIM：To investigate the associations between interleukin（IL）-1B and IL-1RN polymorphisms and gastric cancers among the Tibet,Hui and Han ethnicities.METHODS：Genomic DNA was extracted from peripheral blood of 210,205,and 202 healthy volunteers and from 155,158,and 197 gastric cancer patients from the Tibet,Hui,and Han populations,respectively.Polymorphisms in IL-1B and IL-1RN were analyzed by denaturing high-performance liquid chromatography.RESULTS：Carriers of the IL-1B-31 CC genotype had an increased risk of intestinal type gastric cancer [odds ratio（OR） = 2.17,P = 0.037] in the Tibet ethnicity.Carriers of the IL-1B 2/L genotype had an increased risk of both intestinal and diffuse types of gastric cancer（OR = 2.08,2.31,P = 0.007,0.016,respectively） in the Hui ethnicity.In the Han population,carriers of the IL-1B-31 CC,IL-1B-511CT,TT genotypes had increased risk of intestinal type gastric cancer（OR = 2.51,2.74,5.66,P = 0.005,0.002,0.000,respectively）.CONCLUSION：IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet,Hui,and Han ethnicities in the Qinghai area of China.

关 键 词：Gastric cancer INTERLEUKIN-1B Interleukin1RN POLYMORPHISM Risk of gastric cancer 

分 类 号：R735.2[医药卫生—肿瘤]