国产注射用比伐卢定对大鼠血栓模型血小板活化功能的影响  

Effect of domestic bivalirudin on platelet activation function in rat model of thrombus

作　　者：陈伟宏[1] 吴苏武[1] 张淇钏[1] 向定成[2] 

机构地区：[1]汕头市中心医院重症医学科,515031 [2]广州军区广州总医院心内科,510010

出　　处：《国际医药卫生导报》2013年第1期21-24,共4页International Medicine and Health Guidance News

摘　　要：目的探讨国产注射用比伐卢定（domesticbivalimdin）对大鼠颈总动脉血栓模型血小板活化功能的影响。方法建立大鼠左颈总动脉血栓模型，分为对照组（n=6）、模型组（n=10）、国产注射用比伐卢定联合尿激酶（urokinase，UK）组（B＆UK组，n=10）、肝素（heparin）联合尿激酶组（H＆UK组，n=10），检测各组治疗前后GMP-140含量及血栓重量。结果与模型组比较，B＆UK组及H＆UK组血栓重量均明显减轻，而B＆UK组与H＆UK组之间血栓重量比较差异无统计学意义。模型组、B＆UK组及H＆UK组GMP-140含量均显著高于对照组；而治疗后GMP-140含量在B＆UK组显著低于模型组，相反治疗后GMP-140含量在H＆UK组则显著高于模型组。结论国产注射用比伐卢定能在模型中有效抑制血栓形成，但相比肝素，国产注射用比伐卢定能显著抑制血小板活化功能，抑制血小板聚集。在抑制血栓形成过程中国产注射用比伐卢定对血小板活化的影响具有更多优势。Objectives To explore the effect of domestic bivalirudin on platelet activation function in rat model of carotid artery thrombosis. Methods A rat model of common carotid artery thrombosis was established. The rats were then randomized to control group （n = 6）, model group （n = 10）, domestic bivalirudin plus uroki- nase group （B＆UK, n = 10）, and heparin plus urokinase group （H＆UK, n = 10）. GMP-140 content and thrombus weight were detected before and after treatment. Results As compared with the model group, throm- bus weight was obviously reduced in B＆UK group and H＆UK group. There was no significant difference in thrombus weight between B＆UK group and H＆UK group. GMP-140 content was remarkably greater in the model group, H＆UK group, and B＆UK gourp than in the control group. After treatment, GMP-140 content was signif- icantly increased in H＆UK gourp but obviously reduced in B＆UK gourp. Conclusions Domestic bivalirudin can effectively inhibit formation of thrombosis in the rat model. As compared to heparin, domestic bivalirudin inhibits platelet activation function and platelet aggregation. During inhibition of thrombus formation, domestic bivalirudin has more effects on platelet activation function.

关 键 词：比伐卢定 肝素 颈动脉血栓形成 大鼠 血小板活化 

分 类 号：R-332[医药卫生] R9