慢性丙型肝炎患者红细胞CR1黏附活性与血清TGF-β_1水平的关系  

The Relationship Between the Adherence Activity of Erythrocyte Complement Receptor 1(CR 1) and Serum TGF-β_1 Levels in Patients with Chronic Hepatitis C

作　　者：陈岩 张玉红[2] 

机构地区：[1]江苏省连云港市东海县石榴乡中心卫生院,222300 [2]江苏省连云港市东海县人民医院,222300

出　　处：《放射免疫学杂志》2013年第1期80-81,共2页Journal of Radioimmanology

摘　　要：目的:探讨慢性丙型肝炎患者红细胞CR1黏附活性与血清TGF-β1水平的相关性。方法:采用红细胞天然免疫功能试验和酶联法对32例慢性丙型肝炎患者进行了红细胞CR1黏附活性测定和血清TGF-β1测定,并与35名正常健康人作比较。结果:慢性丙型肝炎患者红细胞CR1黏附活性显著地低于正常人组(P<0.01),血清TGF-β1水平非常显著地高于正常人组(P<0.01),红细胞CR1黏附活性的变化与TGF-β1水平相关。结论:慢性丙型肝炎患者红细胞CR1黏附活性与TGF-β1水平相关,对判断病情的轻重、发生和发展具有一定的临床价值。Objective To explore the correlativity between changes of adheremce activity of erythrocyte CR1 and serum TGF-β1 levels in patients with chronic hepatic C. Methods Erythrocyte CR1 adherence activity was detected with erythrocyte immune function test and serum TGF-β1 level with ELISA in 32 patients with chronic hepatic C and compared to 35 normal healthy controls. Results The erythrocyte CR1 adherence activity in patients with chronic hepatic C showed significantly lower than that controls （ P 〈 0.01 ）, While the serum TGF-β1 level was markedly higher than that in controls（P 〈0.01 ）. The change of CR1 adherence activity was closely correlated with the change of serum TGF-β1 level. Conclusion Change of erythrocyte CR1 adherence activity was closely correlated with the serum TGF-β1. Also, provides certain clinical value to predict the severity of pathosis, pathogeny and development.

关 键 词：慢性丙型肝炎 红细胞 受体 补体 转化生长因子-Β1 

分 类 号：R575.2[医药卫生—消化系统]