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出 处:《中国现代医学杂志》2012年第31期65-66,共2页China Journal of Modern Medicine
摘 要:目的观察紫杉醇与铂类联合化疗治疗晚期卵巢上皮癌的近期疗效及不良反应。方法回顾性分析122例晚期卵巢上皮癌患者采用紫杉醇与铂类化疗,至少完成3个疗程。观察疗效并观察用药后的毒副反应。结果 122例全部参加疗效评价。完全缓解32例,部分缓解64例,稳定20例,进展6例,有效率为78.7%,主要不良反应为骨髓抑制,其中白细胞减少和血小板减少占50%,以Ⅰ~Ⅱ度为主;消化道不良反应发生率93.4%,均为Ⅰ~Ⅱ度。不良反应经对症治疗,很快恢复。结论紫杉醇联合铂类治疗晚期卵巢上皮癌疗效较好,使用简单,不良反应可以耐受。【Objective】 To study the recently curative effect and side effect in combined chemotherapy of paclitaxel and platinum in epithelial ovarian carcinomas(EOCS).【Methods】 On the basis of the retrospective analysis of 122 advanced epithelial ovarian carcinomas patients treated by at least three cycles of paclitaxel and platinum combining chemotherapy,the therapeutic effect and treatment toxicity were observed.【Results】 All of the 122 cases were involved in the efficacy evaluation.Among them,32 were CR,64 were PR,20 were SD and 6 were progressing.The total rate of recovery was 78.7%.The side effect mainly showed up in Ⅰ~Ⅱ arrest of bone marrow with the 50% reduction of leukocytes and platelets.The occurrence rate of the Ⅰ~Ⅱ adverse gastrointestinal reaction was 93.4%.By symptomatic treatment,the adverse reactions recovered soon.【Conclusions】 With the tolerable adverse reaction,the therapeutic effect of paclitaxel combined with platinum for advanced epithelial ovarian carcinomas is good and this treatment is easy to be operated.
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