液相色谱-串联质谱法测定食品接触材料中28种初级芳香胺的迁移量  被引量:27

Determination of Migration of 28 Primary Aromatic Amines from Food Contact Materials by Liquid Chromatography-Tandem Mass spectrometry

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作  者:李全忠[1] 周明辉[1] 刘莹峰[1] 翟翠萍[1] 郑建国[1] 王云玉[1] 

机构地区:[1]广东出入境检验检疫局,广州510623

出  处:《分析化学》2013年第1期25-30,共6页Chinese Journal of Analytical Chemistry

基  金:国家质检总局科技计划项目(No.2010IK039)资助

摘  要:建立了液相色谱-串联质谱法(LC-MS/MS)同时测定食品接触材料中28种初级芳香胺(PAAs)迁移量的方法。采用C3色谱柱,以甲醇-水为流动相,梯度洗脱分离,在电喷雾正离子模式下以多反应监测(MRM)方式检测,外标法定量。28种PAAs检出限(LOD,S/N=3)和定量限(LOQ,S/N=10)分别为0.02~0.3μg/kg和0.1~1.0μg/kg;在1.0~1000μg/L浓度范围内线性良好,相关系数大于0.9915;加标浓度在1.0~100μg/kg的回收率为77.8%~105.3%;相对标准偏差(RSD)为4.5%~11.8%。本方法操作简便、快速、准确、灵敏度高,能满足相关测定要求。A method was developed for simultaneous determination of the migration of 28 kinds of primary aromatic amines(PAAs) from food contact materials by liquid chromatography-tandem mass spectrometry (LC- MS/MS). The analytes were separated on a Ca column,eluted by gradient with methanol and water, identified by electrospray ionization mass spectrometry in positive mode using multiple reaction monitoring (MRM), quantified by external standard method. The limits of detection ( LOD, S/N = 3 ) and quantification ( LOQ, S/N= 10) of 28 PAAs were 0.02-0.3 μg/kg and 0.1-1.0μg/kg, respectively. The correlation coefficients of linear calibration curve were over 0. 9915 in the ranges varied from 1.0 μg/L to 1000 μg/L. The recoveries of PAAs were 77.8% -105.3% in the spiked range of 1.0-100 μg/kg, and the relative standard deviation (RSD) was 4.5%-11.8%. The experiment results indicated that the method was simple, rapid, sensitive, accurate, and could meet the correlative requirements for determination.

关 键 词:液相色谱-串联质谱(LC-MS/MS) 食品接触材料 初级芳香胺 迁移量 

分 类 号:O657.63[理学—分析化学]

 

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