老年抑郁症发病机制的研究进展  

Research Progress in the Pathogenesis of Late Life Depression

作　　者：黄世敬[1] 雷小明[1] 张颖[1] 

机构地区：[1]中国中医科学院广安门医院中药研发中心,北京100053

出　　处：《医学综述》2013年第1期1-4,共4页Medical Recapitulate

基　　金：国家自然科学基金(81072801);北京市自然科学基金(7093129)

摘　　要：老年抑郁症(LLD)发病率高,危害严重,是老年人群中重大的公共卫生问题。LLD的发病与年龄、性别、疾病和营养、人格特质及社会因素等有关,其病理机制与血管损害、脑白质病变、情感中枢神经元丢失、情感神经递质变化、神经内分泌、炎性介质、神经元可塑性、神经生物化学、电生理学改变等有关。上述认识有益于LLD的早期预防、早期识别和及时干预。Late life depression（ LLD ）is a disease with high incidence and serious harmness, which is a major public health problem for the elderly. The pathogenesis of LLD is associated with age,gender,diseases and nutrition, personality and social factors, and its pathological mechanisms include vascular impairment, brain white matter lesions, emotional central neurons loss, emotional neurotransmitters change, and neuroen- docrine,inflammation and neurons plasticity, nerve biochemistry, electric physiology changes. These cogni- tions are beneficial to early prevention, early recognition and timely intervention of LLD.

关 键 词：老年抑郁症 风险因素 发病机制 

分 类 号：R749.4[医药卫生—神经病学与精神病学]