胃癌中CD_(147)和基质金属蛋白酶9的表达及意义  

Expression of CD_(147) and MMP9 in Gastric Cancer and Its Significance

作　　者：张乐天[1] 鲍祖友 

机构地区：[1]淮南市朝阳医院消化科,安徽淮南232007 [2]淮南市朝阳医院肿瘤科,安徽淮南232007

出　　处：《医学综述》2013年第1期163-165,共3页Medical Recapitulate

摘　　要：目的探讨CD147和基质金属蛋白酶9(MMP9)在胃癌中的表达及意义。方法应用免疫组织化学SP法检测70例胃癌及20例癌旁组织中CD147和MMP9的表达情况。对所有数据应用SPSS 17.0软件进行统计分析处理,率的比较采用χ2检验,等级资料采用秩和检验,相关性采用Spearman检验。结果 CD147及MMP9在20例癌旁组织中阳性表达率分别为15%和10%;CD147、MMP9在胃癌中的阳性表达率分别为68.6%和72.9%(均P<0.01)。CD147和MMP9的表达均与胃癌患者的浸润深度及淋巴结转移相关(均P<0.05),与组织学分型及肿瘤分化程度无相关性(均P>0.05)。CD147和MMP9在胃癌中表达呈显著正相关(r=0.828)。结论 CD147和MMP9在胃癌中高表达,两者在胃癌的发生、发展中可能发挥着重要作用。Objective To investigate expression of CD147 and atrix mctallopreteinase-9 （MMPg）in gas- tric cancer and its significance. Methods The expressions of CD147 and MMP9 in 70 cases with gastric cancer and 20 cases with paraneoplastic of the gastric cancer were detected by immunohistoehemical SP method. SPSS17.0 software was used to process all data, X2 test was used for the ratio comparison, level in- formation was tested by rank sum test, correlation was analyzed by Spearman test. Results In 20 specimens with paraneoplastic of the gastric cancer, the expressions of CD147 and MMP9 were 15% and 10% ;the ex- pressions of CD147 and MMP9 in gastric cancer were 68.6% and 72.9% （ all P 〈0.01 ）. The expressions of CD147 and MMP9 in gastric cancer were related to depth of invasion and lymph node metastases（ both P 〈 0.05）, but not related to tumor histological type or tumor differentiation （ both P 〉 0.05 ）. Expression of CD147 was positively correlated to MMP9 （r = 0. 828）in gastric cancer. Conclusion CD147 and MMP9 are over expressed in gastric cancer,which may play an important role in the genesis and development of gastric cancer.

关 键 词：胃肿瘤 免疫组织化学 CD147 基质金属蛋白酶9 

分 类 号：R735.2[医药卫生—肿瘤]