PPARγ在心血管疾病防治中的临床价值  

Clinical Value of PPARγ in Cardiovascular Diseases

作　　者：周昱[1] 吴升华[1] 

机构地区：[1]南京医科大学第一附属医院儿科,南京210029

出　　处：《医学综述》2013年第2期225-227,共3页Medical Recapitulate

摘　　要：过氧化物酶增殖体活化受体γ(PPARγ)是调节目的基因表达的核转录因子超家族成员,主要表达于脂肪组织及免疫系统,与脂肪细胞分化、机体免疫及胰岛素抵抗密切相关。此外,它还表达于血管壁细胞和心肌细胞,发挥抗心肌细胞肥大、抗炎、抗氧化和抗增殖的作用。近年来研究发现,PPARγ及其配体不仅能增强对胰岛素的敏感性,也在动脉粥样硬化、心肌肥大、心肌缺血和心肌炎等多种心血管疾病中发挥作用。Peroxisome proliferator-activated receptor-γ（PPARγ） is a member of the nuclear receptor su- perfamily. PPARγ is expressed predominantly in adipose tissue and immune system, and closely associated with adipoeyte differentiation, immune and insulin resistance. PPAR-γ is also present in a variety of cell types including vascular wall cells and cardiomyocytcs, exerting the roles of antthypertrophy of cardlomyocytes and anti-inflammatory, antioxidative, and antiproliferative effects. Recent studies suggest that PPARγ and its ligands not only ameliorate insulin sensitivity, but also have pleiotropic effects on the pathophysiology of ath- erosclerosis , cardiac hypertrophy, myocardial ischemia , and myocarditis.

关 键 词：过氧化物酶增殖体活化受体γ 炎症 心血管疾病 

分 类 号：R365[医药卫生—病理学]