Wnt和Notch信号通路在肺癌干细胞调控中的研究进展  

The Research Progress of Wnt and Notch Pathways in the Regulation of Lung Cancer Stem Cells

作　　者：况里杉 罗虎 周向东 

机构地区：[1]第三军医大学第一附属医院呼吸内科,重庆400038

出　　处：《医学综述》2013年第2期268-271,共4页Medical Recapitulate

基　　金：国家重点基础研究发展计划(973计划)(2010CB529400)

摘　　要：肿瘤干细胞是具有自我更新和多向分化潜能的少部分未分化细胞,在多种肿瘤的发生、发展中发挥重要作用。肺癌干细胞被认为是肺癌发生的根源,具有自我更新、分化、转移、致瘤性等特征。已有研究表明,肺癌干细胞受自身内在基因和其所处微环境信号的共同调控,两条经典的发育调控通路Wnt、Notch在其中发挥重要作用。深入研究Wnt和Notch信号通路在肺癌干细胞调控中的作用,有望在肺癌的诊断及治疗中找到新靶点。Cancer stem ceils which have self-renewal and multi-directional differentiation potential are a small number of undifferentiated cell group and they play an important role in the development and progres- sion of human tumors. The lung cancer stem cells were thought to be the root of lung cancer with renewal, dif- ferentiation, metastasis and tumorigenesis capacity. Recent researches indicate that lung cancer stem cells are under the co-regulation of the inside genes themselves and the microenvironmental signals around them. Wnt and Notch signal pathways which are two classic development regulation pathways play important roles in them. The profound research on Wnt and Notch signal pathways in the regulation of lung cancer stem ceils is beneficial to the discovery of potential targets for the treatment and diagnosis of lung cancer.

关 键 词：肺癌干细胞 调控 WNT信号通路 NOTCH信号通路 

分 类 号：R734.2[医药卫生—肿瘤]