依达拉奉联合硫酸镁和大剂量纳洛酮治疗急性脑卒中的临床观察  

Clinical Observation of Edaravone Combined with Magnesium Sulfate and Large doses of Naloxone as the Treatment of Acute Stroke

作　　者：孙静[1] 孙成[1] 聂志敏[1] 张华亮[1] 万鹏[1] 

机构地区：[1]武警江西总队医院,南昌330000

出　　处：《医学综述》2013年第2期375-377,共3页Medical Recapitulate

摘　　要：目的探讨依达拉奉联合硫酸镁和大剂量纳洛酮治疗急性脑卒中的疗效。方法 112例急性脑卒中患者按随机数字表法分为观察组和对照组,每组46例。对照组给予依达拉奉,观察组联合应用硫酸镁、大剂量纳洛酮。比较两组神经功能缺损评分、血液流变学指标及疗效。结果观察组总有效率为86.96%(40/46),对照组为60.87%(36/46),比较差异有统计学意义(P<0.01);两组治疗后NDS评分和血液流变学指标均显著下降(P<0.05),观察组较对照组下降更为显著,比较差异有统计学意义(P<0.05);两组均无不良反应。结论依达拉奉联合硫酸镁和大剂量纳洛酮治疗急性脑卒中能更快改善神经功能,促进血液循环,显著提高疗效,且无不良反应。Objective To investigate the efficacy of edaravone combined with magnesium sulfate, and large doses of naloxone as the treatment of acute stroke. Methods 112 cases of acute stroke patients were divided into the observation group and control group with 46 cases in each group according to random number table. The control group was given edaravone ; the observation group combined with magnesium sulfate, and large doses of naloxone. Neurological function, hemorheological indexes and efficacy were compared between the two groups. Results The total effective rate of the observation group was 86.96% （40/46） , of the con- trol group was 60.87 % （36/46） , the difference was statistically significant （P 〈 0.01 ） ; the NDS score and hemorbeological indexes of two groups were significantly lower after treatment （ P 〈 0.05 ） , the observation group decreased more significantly than the control group （ P 〈 0.05 ） ; there were no adverse reactions in both groups. Conclusion Edaravane combined with magnesium sulfate,and large doses of nalnxone treating acute stroke can improve nerve function quickly,promote blood circulation and significantly improve the effi- cacy, without adverse reactions.

关 键 词：依达拉奉 硫酸镁 纳洛酮 急性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]