卡马西平对癫痫患者血同型半胱氨酸、叶酸、维生素B_(12)水平的影响  

Effect of carbamazepine on the levels of homocysteine, folic acid, vitamin B_(12) in patients with epilepsy

作　　者：张其梅[1] 夏杰[1] 张建宇[1] 

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院神经内科,湖北宜昌443003

出　　处：《海南医学》2013年第1期11-12,共2页Hainan Medical Journal

摘　　要：目的探讨卡马西平(Carbamazepine,CBZ)对血同型半胱氨酸(Homocysteine,Hcy)、叶酸、维生素B12(vitaminB12,VitB12)水平的影响。方法分别检测CBZ单药治疗癫痫患者(CBZ组)的血Hcy、叶酸、VitB12水平,并与未服用抗癫痫药的患者(癫痫对照组)及健康对照组进行比较。结果 CBZ组患者血Hcy水平明显高于癫痫对照组和正常对照组(P<0.01),叶酸水平低于癫痫对照组和正常对照组(P<0.05),VitB12水平有下降趋势,但与两对照组比较,差异无统计学意义(P>0.05)。结论 CBZ可引起癫痫患者血Hcy水平升高和叶酸水平降低;长期服用CBZ的癫痫患者应监测血Hcy、叶酸、VitB12浓度,及时补充叶酸和B族维生素,以预防血栓事件的发生。Objective To investigate the effect of carbamazepine （CBZ） on the levels of homocysteine （Hey）, folio acid, vitamin BI~ （VitBi2）. Methods The levels of blood Hey, folio acid, VitB12 were measured in epilepsy patients treated by CBZ （CBZ group）, epilepsy patients not treated by CBZ （the epilepsy control group）, healthy individuals （the normal control group）. The results were compared between the three groups. Results The blood Hey levels in CBZ group were significantly higher than those in the epilepsy control group and the normal control group （P〈0.01）, while the levels of folic acid were significantly lower （P〈0.05）. The levels of VitB12 exhibited a downward trend in CBZ group, but showed no statistically significant difference with the other two groups. Conclusion CBZ can elevate the levels of Hcy and reduce the level of folic acid in patients with epilepsy. Epilepsy patients taking CBZ for a long time should be monitored for the levels of blood Hey, folio acid, VitB12 and timely supplemented with folic acid and B vitamins in order to prevent the occurrence of thromboembolic events.

关 键 词：卡马西平 癫痫 同型半胱氨酸 叶酸 维生素B 

分 类 号：R742.1[医药卫生—神经病学与精神病学]