新疆维吾尔族与汉族食管癌组织中HIF-1α、Survivin、CyclinD1蛋白的表达及其意义  

Expression of HIF-1α,Survivin,CyclinD1 in esophageal cancer in Xinjiang Uygur people and Han people and its significance

作　　者：王剑云[1] 宋晓平[2] 柴小军[1] 宏刚[2] 郑健[1] 臧丽娟[3] 

机构地区：[1]上海交通大学附属第一人民医院胸外科,上海200083 [2]阿克苏地区第一人民医院胸外科,新疆阿克苏843000 [3]上海交通大学附属第一人民医院病理科,上海200083

出　　处：《海南医学》2013年第2期166-168,共3页Hainan Medical Journal

基　　金：上海市科学技术委员参与西部开发科技合作项目(编号:09415802000)

摘　　要：目的探讨HIF-1α、Survivin、CyclinD1蛋白在新疆维吾尔族和汉族食管癌组织中的表达及意义。方法应用免疫组化技术检测80例不同民族食管癌组织中HIF-1α、Survivin、CyclinD1蛋白的表达。结果食管癌组织中HIF-1α、Survivin、CyclinD1蛋白在不同民族间的阳性表达率差异均无统计学意义(P>0.05)。三者阳性表达率均与肿瘤浸润深度以及淋巴结转移相关(P<0.05)。Survivin阳性表达率与肿瘤分级相关。HIF-1α与Survivin、CyclinD1的表达呈正相关(P<0.05)。结论 (1)食管癌组织内HIF-1α、Survivin、CyclinD1蛋白表达在新疆维吾尔族与汉族之间差异无统计学意义。(2)检测三者蛋白的表达有助于判断食管癌的恶性程度以及推断临床预后。Objective To investigate the expression ofHIF-lct, Survivirg CyclinD1 in esophageal cancer in Xinjiang Uygur people and Han people, and to analyze its significance. Methods The levels of HIF-1α Survivin, CyclinD1 proteins were investigated in esophageal caner tissues of 80 people by immunohistochemical technique. Results There was no statisti- cally significant difference in the expression of HIF-1α, Survivin, CyelinD1 between Xinjiang Uygur people and Han people （P〉0.05）. There were close relations between the positive expression rate of HIF-1α, Survivin, CydinD1 protein and the depth of tumor invasion as well as lymphnode metastasis （P〈0.05）. The expression of HIF-1α was positively correlated with the ex- pression of Survivin, CydinD1 protein （P〈O.05）. Conclusion （1） Xinjiang Uygnr people and Han people showed no differ- ence in the expression ofHIF-1α, Survivin, CyclinD 1 in the tissues of esophageal cancer. （2） The determination of the three pro- teins is helpful for evaluating the invasion and the lymphnode metastasis as well as for predicting the prognosis.

关 键 词：食管癌 HIF-1Α SURVIVIN CYCLIND 1 免疫组化 民族 

分 类 号：R735.1[医药卫生—肿瘤]