利培酮和氯氮平治疗精神分裂症疗效评价及其对糖、脂代谢的影响分析  

Clinical efficacy of risperidone and clozapine treatment for schizophrenia and the impact on glucose and lipid metabolism

作　　者：刘洪光[1] 曾志强[1] 王元彬[1] 叶昌斌[1] 

机构地区：[1]深圳市康宁医院检验科,广东深圳518020

出　　处：《国际检验医学杂志》2013年第1期33-35,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨利培酮和氯氮平治疗精神分裂症初诊患者的临床疗效及其对糖脂代谢的影响。方法 94例精神分裂症初诊患者分为利培酮组和氯氮平组,治疗8周后评价临床疗效,测定并比较治疗前后患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、空腹血糖(FBG)、空腹胰岛素(Fins)、胰岛素抵抗指数(IRI)及胰岛素敏感指数(ISI)水平。结果两组患者治疗总有效率无统计学差异(P>0.05)。两组患者治疗后血浆TC、TG、LDL、FBG、Fins、IRI水平升高,HDL、ISI水平降低(P<0.05),氯氮平组TC、TG、LDL水平升高幅度、HDL降低幅度大于利培酮组(P<0.05)。结论氯氮平和利培酮对精神分裂症初诊患者临床疗效确切,二者均对患者糖、脂代谢有影响;利培酮对患者脂代谢的影响相对较小,可作为患者临床治疗的首选用药。Objective To investigate the clinical efficacy of risperidone and clozapine for treating patients with first-case schizophrenia and the impact on glucose and lipid metabolism. Methods 94 patients with first-case schizophrenia were randomly divided into risperidone group and clozapine group. After treatment of 8 weeks, clinical efficacy was evaluated. The pre-treatment and pro-treatment total cholesterol（TC）,triacylglycerol（TG）, low density lipoprotein（LDL）, high density lipoprotein（HDL）, fasting blood glucose（FBG） and fasting insulin（Fins）,insulin resistance index（IRI）,insulin sensitivity index（ISI） levels of the two groups were detected and compared. Results The total effective rate of the two groups was with no statistical difference（P〉0.05）. After treatment, the plasma TC, TG, LDL, FBG, Fins and IRI levels of two groups significantly increased, the HDL, ISI levels significantly decreased（P〈0.05） ,and the increase extent of TC,TG and LDL level and the decrease extent of HDL level of the clozapine group Was more obvious than the risperidone group（P〈0.05）. Conclusion The clinical efficacy of clozapine and risperidone for treating first-case schizophrenia could be exact, both of which might have impact on glucose and lipid metabolism. Risperidone could have relatively weaker affect and could be used as the first choice for treating first-case schizophrenia.

关 键 词：精神分裂症 利培酮 氯氮平 糖代谢 脂代谢 

分 类 号：R749.3[医药卫生—神经病学与精神病学]