慢性肝病患者血清四项指标联合检测的临床价值  

Clinical value of combined detection of four serum indicators in chronic liver disease patients

作　　者：黄连贵[1] 任重[1] 任力[1] 赵春艳[1] 李杰[1] 

机构地区：[1]湖北省松滋市人民医院,湖北松滋434200

出　　处：《国际检验医学杂志》2013年第2期167-168,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原氨端肽(PⅢNP)和Ⅳ型胶原(Ⅳ-C)检测在慢性肝病中的临床价值。方法对103例慢性肝病患者的血清HA、LN、PⅢNP和Ⅳ-C四项指标进行检测分析。结果慢性迁延性肝炎(CPH)组、慢性活动性肝炎(CAH)组和肝硬化(LC)组的血清HA、LN、PⅢNP、Ⅳ-C检测结果均增高,与对照组比较差异均有统计学意义(P<0.01),且四项指标在CPH组、CAH组、LC组的浓度呈上升趋势。在30例LC患者中,血清HA的阳性率达90.0%,远高于清蛋白(56.6%),差异有统计学意义(P<0.01)。结论血清HA、LN、PⅢNP、Ⅳ-C四项指标是慢性肝病向肝硬化转变过程中反映肝纤维化进展的良好指标,四项指标联合检测可以为慢性肝病患者肝纤维化早期诊断提供依据。Objective To explore the clinical value of serum hyaluronic acid,laminin,N-terminal procollagen Ⅲ and collagen type Ⅳ in chronic liver disease patients.Methods Serum HA,LN,PⅢNP and Ⅳ-C of 103 chronic liver disease patients were detected and analyzed from January 2010 to January 2011.Results Serum concentrations of HA,LN,PⅢNP,Ⅳ-C in patients with chronic persisting hepatitis（CPH）,chronic active hepatitis（CAH） and liver cirrhosis（LC） were significantly increased,compared with control group（P0.01）.The concentrations of four indicators were rising in CPH group,CAH group,and LC group.The positive rate of HA was 90.0% in 30 liver cirrhosis patients,while the positive rate of serum albumin was 56.6%.There was significant difference between them（P0.01）.Conclusion Serum HA,LN,PⅢNP,Ⅳ-C are good indicators that reflect liver fibrosis progression in the transformation of from chronic liver disease to hepatic sclerosis.Combined detection of four indicators can provide basis for early diagnosis of liver fibrosis in chronic liver disease patients.

关 键 词：透明质酸 层黏连蛋白 Ⅲ型前胶原氨端肽 Ⅳ型胶原 慢性肝病 

分 类 号：R575.2[医药卫生—消化系统]