儿童原发性颞叶癫痫海马体积的MRI研究  

MRI study of hippocampal volume measurement in idiopathic temporal lobe epilepsy in children

作　　者：张玉珍[1] 高煜[1] 张忠阳[1] 李芳珍[1] 刘明[1] 李玉华[1] 

机构地区：[1]交通大学医学院附属新华医院放射科,上海200092

出　　处：《放射学实践》2013年第1期83-87,共5页Radiologic Practice

摘　　要：目的:评价T1加权三维磁化强度预备梯度回波序列(3D-MPRAGE)在儿童原发性颞叶癫痫(TLE)海马体积(HCV)测量中的作用,分析TLE病例HCV改变的可能影响因素。方法:对原发性颞叶癫痫儿童(病变组,24例)及健康对照组(NC组,24例)儿童分别行手动HCV测量。按年龄组(<6岁组、6～9岁组、9～13岁组)对两组数据进行统计学比较。结果:病变组和对照组在<6岁患儿中总HCV差异有统计学意义(P=0.02),在另两个年龄组中差异无统计学意义(6～9岁组P=0.9535,9～13岁组P=0.9822)。<6岁病变组左、右侧HCV差异有统计学意义(P=0.0018),而在6～9岁、9～13岁病变组及对照组3个年龄组内差异均无统计学意义。对照组2～13岁儿童HCV范围为(2020.25±26.89)～(2100.93±57.33)mm3。结论:3D-MPRAGE可清晰显示海马及相关脑组织结构,具有较高的应用价值。<6岁儿童原发性颞叶癫痫HCV改变可能与癫痫发作次数、持续时间、发作后距MRI检查时间等多种因素有关。正常儿童HCV范围的测定可作为评价海马病变的参考之一。Objective：To assess the value of TI W 3D magnetization prepared rapid acquisition gradient echo imaging （3D MPRAGE） in measurement of hippocampal volume （HCV） in pediatric idiopathic temporal lobe epilepsy （TLE）, and to analyze the factors causing change of HCV in TLE patients. Methods： Manual measurement of HCV by 3D-MPRAGE was performed in TLE patients （n= 24） and control （NC） subjects （n= 24）, which were further divided into three groups according to age （〈6y,6-9y and 9- 13y）. The data of these TLE and NC groups were analyzed statistically and com- pared. Results：In the group of 〈6 years of age, significant differences of HCV change was existed between TI.E and NC （P=0.02） ,while no significant statistical differences were showed in 6-9y （P= 0. 09535） and 9- 13 y （P：0. 09822） groups. There was significant difference in the HCV of the left and right side in the 〈6y TLE group （P=0. 0018） ,yet no difference was existed in the 6-9y,9-13y TLD patients as well as the 3 groups of NC. The HCV of normal children with the age ranged from 2-13 years old were （2020.25±26.89）mm3 to （2100.93±57.33）ram3 in this study. Conclusion：3D- MPRAGE was valuable in showing the hippocampus and relative cerebral structures,with significant value in clinical appli- cation. The change of HCV in%6y TLE group may be related to various factors including frequency of seizure,duration and time of MR examination after seizure. MRI measurement of HCV in normal children could be as a reference for evaluation of hippocampal lesions.

关 键 词：海马 海马体积 磁共振成像 癫痫 颞叶 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]