^(18)F-FDG PET/CT在淋巴瘤结外侵犯中的诊断价值  

The value of ^(18)F-FDG PET/CT in the diagnosis of extranodal invasion of lymphoma

作　　者：陈光祥[1] 蔡亮[2] 张伟[2] 黄占文[2] 陈跃[2] 唐光才[1] 

机构地区：[1]泸州医学院附属医院放射科,四川646000 [2]泸州医学院附属医院核医学科,四川646000

出　　处：《放射学实践》2013年第1期95-98,共4页Radiologic Practice

摘　　要：目的:探讨18F-FDG PET/CT在淋巴瘤结外侵犯中的诊断价值。方法:回顾性分析经穿刺活检、手术病理证实或临床综合诊断为淋巴瘤结外侵犯的27例患者的临床和PET/CT资料。结果:27例结外侵犯的淋巴瘤中,PET/CT共发现74个18F-FDG摄取异常增高的淋巴瘤结外侵犯病灶,平均SUVmax为6.3±2.1,其中胃肠道10例(14个病灶)、脾脏4例(5个病灶)、鼻咽、口咽部3例(7个病灶)、肝脏3例(4个病灶)、骨骼2例(21个病灶)、肺组织2例(5个病灶)、腹膜1例(7个病灶)、膈肌1例(3个病灶)、腮腺1例(2个病灶)、肌肉1例(2个病灶)、皮肤1例(2个病灶)、鼻中隔1例(1个病灶)、睾丸1例(1个病灶)。PET/CT对淋巴瘤结外侵犯病灶的诊断符合率为94.0%(79/84),灵敏度为96.1%(74/77),特异度为71.4%(5/7),阳性预测值为97.4%(74/76),阴性预测值为62.5%(5/8)。结论:18 F-FDG PET/CT代谢成像能准确显示淋巴瘤结外侵犯全身病灶,具有重要的临床应用价值。Objective：To study the value of 18F-FDG PET/CT in the diagnosis of extranodal invasion in patients with lymphoma. Methods： The clinical and 18 F-FDG PET/CT materials in 27 patients with lymphoma having extranodal invasion proved by aspiration biopsy, surgery and pathology or comprehensive clinical diagnosis were retrospectively analysed. Results：Of the 27 patients, totally 74 extranodal lesions with abnormally increased 18F-FDG uptake were found by PET/ CT, with the mean of maximum standardized uptake value （SUV） as 6.3 4-2.1. There were gastrointestinal invasion （10 ca- ses, 14 lesions）, spleen invasion （4 cases, 5 lesions）, nasopharyngeal and oropharyngeal invasion （3 cases, 7 lesions）, hepatic invasion （3 cases,4 lesions）,bone invasion （2 cases,21 lesions）,pulmonary invasion （2 cases,5 lesions）,peritoneal infiltra- tion （one case, 7 lesions）, diaphragmatic infiltration （one case, 3 lesions）, parotid infiltration （one case, 2 lesions）, muscle infiltration （one case, 2 lesions）, dermal infiltration （one case, 2 lesions）, nasal septal infiltration （one case, 1 lesion）, testicle lesion （one case, lesion）. The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of PET/ CT in diagnosing extranodal lymphoma were 94.0% （79/84）,96.1% （74/77）,71.4% （5/7） ,97. 4% （74/76）,62.5% （5/ 8）, respectively. Conclusion：The metabolic imaging of 18 F-FDG PET/CT can accurately show lesions of extranodal invasion of lymphoma in the body and provides very important clinical value.

关 键 词：正电子发射断层显影术 体层摄影术 X线计算机 淋巴瘤 淋巴细胞 肿瘤浸润 

分 类 号：R733.1[医药卫生—肿瘤]