AZ31镁合金修复兔下颌骨缺损的实验研究  

Repair of Mandibular Defects with AZ31 Magnesium Alloy in Rabbits

作　　者：王树峰[1] 王程越[2] 姚玉胜[3] 赵远[3] 魏来[3] 杨柯[4] 

机构地区：[1]辽宁医学院研究生学院,辽宁锦州121000 [2]锦州市中心医院口腔科 [3]辽宁医学院附属第二医院口腔科 [4]中国科学院金属研究所

出　　处：《口腔医学研究》2013年第1期33-36,共4页Journal of Oral Science Research

基　　金：辽宁省教育厅课题资助项目(编号:2009T063)

摘　　要：目的:研究用于修复兔下颌骨缺损的AZ31镁合金降解、金属-骨界面结合及成骨情况。方法:制备兔下颌骨颊侧7mm×5mm×2mm骨开窗样缺损,分别植入未处理的AZ31镁合金(A组)、微弧氧化处理的AZ31镁合金(B组)、缺损处不修复(C组)。术前1d及术后第1、2、4、8、12周取兔动脉血和尿液,测定镁离子浓度。术后3个月处死动物,进行大体观察、SEM、组织学观察。结果:A、B组血中镁离子浓度在术前后无显著性差异;术后第2周A组尿中镁离子浓度比术前明显升高;B组无显著性差异。术后3个月A组仅形成类软骨样组织,B组有新骨形成且有部分覆盖材料表面,C组无骨组织形成;SEM显示A组材料表面出现明显层状崩解,B组降解不明显;组织学检查显示A组材料周围有软骨样组织,B组材料周围有大片状新骨形成,C组为纤维组织修复。结论:微弧氧化在一定程度上降低了镁合金的降解速率;其表面形成陶瓷层具有生物活性可有效避免排异反应。Objective： To investigate degradation, metals-bone interface and bone formation of AZ31 magnesium alloy in bone defects repair. Methods： A 7 mm× 5 mm× 2mm defect was made in rabbit each mandibular buecal side. The detects were implanted with untreated AZ31 magnesium alloy （group A）, micro-arc oxidation treated AZ31magnesium alloy （group B）, or without repair （group C）. The concentrations of magnesium ion in blood and urine were measured at pre-operatively 1 day, post-operatively 1,2,4,8 and 12 weeks. Rabbits were sacrificed at three months. The defects were evaluated by gross observation, SEM and histology. Results： Magnesium ion con centration in blood of group A and B has fluctuation in the normal range （0.82-2.22mmol/1）and there was no significant difference before and after surgery. Two weeks after operative, magnesium ion concentration in urine of group A was significantly increased compared with pre-operative（P〉0.05）. Magnesium ion concentration in urine of group B has no significant difference between preoperative and postoperative. Three months after surgery, metals -bone tissue of group B bound more closely than group A, only cartilage-like tissue formed around group A, no bone formed and fibrous connective tissue filled the bone defect area of group C. SEM observation indicated that the surface of group A had layered disintegration ,while degradation was not obvious in group B. Histological observa- tion showed that the cartilage-like tissue was around group A, and a large sheet of new bone around group B, only fibrous tissue in group C. Conclusion： Micro-arc oxidation reduces the degradation rate of magnesium alloy in cer tain extent. Micro--are oxidation treated AZ31magnesium alloy has bone induction.

关 键 词：AZ31镁合金 降解性 微弧氧化 

分 类 号：R782.4[医药卫生—口腔医学]