HGF/C-Met在舌部鳞状细胞癌的表达及其临床意义  

Expression of Hepatocyte Growth Factor(HGF) and c-Met in Squamous Cell Carcinoma of the Oral Tongue(SCCOT)

作　　者：陈仲伟[1] 徐冬贵[1] 朱李军[1] 王启朋[1] 冯航[1] 江穗[1] 

机构地区：[1]广东省人民医院.广东省医学科学院口腔颌面外科,广东广州510080

出　　处：《口腔医学研究》2013年第1期76-81,共6页Journal of Oral Science Research

基　　金：广东省科技计划项目(编号:2012B030301182)

摘　　要：目的:探讨肝细胞生长因子及其受体C-Met蛋白在舌鳞癌中的表达与其临床病理特征之间的关系。方法:通过免疫组化法检测10例正常舌组织、14例舌癌前病变及63例舌鳞癌中肝细胞生长因子、C-Met的表达,数据通过SPSS13.0统计软件非参数秩和检验统计。结果:肝细胞生长因子和C-Met在舌癌、舌癌前病变及正常舌组织的阳性表达率分别为84.1%、57.1%、40.0%和76.2%、35.7%、20.0%,其表达差异均具有统计学意义(P<0.05)。在中、低分化组(90.3%)及有淋巴结转移组(100%)舌鳞癌中肝细胞生长因子的阳性表达率显著高于高分化组(78.1%)及无转移淋巴结组(76.7%);在Ⅲ、Ⅳ期(82.1%)及有淋巴结转移组(85.0%)的舌鳞癌中C-Met阳性表达率显著高于Ⅰ、Ⅱ期(71.4%)及无转移淋巴结组(72.1%),表达差异均具有统计学意义(p<0.05);63例舌癌组织切片中46例HGF及C-Met都有阳性表达,其在舌鳞状细胞癌中的表达显著正相关(P<0.01)。结论:过度表达的HGF/C-Met可作为判断舌鳞状细胞癌生物学行为、恶性潜能和预测淋巴结转移趋势的参考指标。Objective： To evaluate the relationship of the expression of hepatocyte growth factor （HGF）/c-Met and clinical and pathologic characteristics of patients with squamous cell carcinoma of the oral tongue（SCCOT）. Methods： Tumors from 63 patients with SCCOT, precancerous lesions of tongue from 14 patients and normal tissues of the tongue from 10 patients were evaluated for the expression of HGF and c-Met by immunohistochemistry. Results： The positive rates of HGF and c-Met immunostaining in SCCOT were 84.1 % and 76.2% respectively, which was significantly higher than that of the precancerous and normal groups （57.10%, 35.7 % and 40.0 %, 20. 0 %）. The HGF/c-Met staining was significantly correlated with lymph node metastasis（P〈0.05）, tumor classification（P〈0.05） and TNM pathologic stages. There was a positive relationship between HGF and c-Met expression in SCCOT. Conclusion： HGF and c-Met expression may play an important role in the growth, invasion and metastasis of SCCOT. HGF and c-Met could serve as an important index to estimate the biologic behavior of SCCOT.

关 键 词：肝细胞生长因子(HGF) C-MET 舌鳞状细胞癌 

分 类 号：R739.86[医药卫生—肿瘤]