卵巢类似性索-间质肿瘤子宫内膜样腺癌临床病理观察  

Ovarian endometrioid adenocarcinoma resembling sex-cord tumors:a chlincopathologic study

作　　者：马怡晖[1] 赵庆夏[1] 李惠翔[1] 

机构地区：[1]郑州大学第一附属医院病理科,郑州450052

出　　处：《临床与实验病理学杂志》2013年第1期45-48,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨卵巢类似性索-间质肿瘤子宫内膜样腺癌(ovarian endometrial carcinoma resembling sex cord-stromal tumor,EC-SCS)的临床病理特征、免疫表型和鉴别诊断。方法对1例ECSCS进行HE和免疫组化SP染色,并复习相关文献。结果镜检:肿瘤90%以上区域由胞质透亮的梭形或短梭形细胞构成,其内混有实性条索状或中空小管样结构,类似Sertoli细胞肿瘤;仅有不到10%的区域表现为经典的子宫内膜样腺癌。免疫表型:肿瘤细胞弥漫表达CK、CK7、EMA、ER,不表达α-inhibin、PLAP以及CA125。结论 ECSCS与卵巢性索-间质肿瘤在形态上易混淆。在组织充分取材的基础上仔细寻找镜下经典的子宫内膜样腺癌的结构并结合免疫表型,有助于诊断。Purpose To investigate the clinicopathological features, immunophenotype and differential diagnosis of ovarian endometrial carcinoma resembling sex eord-stromal tumor （ECSCS）. Methods One case of ECSCS was studied by HE and immunohistochemieal staining and the literatures were reviewed. Results Microscopically, more than 90% of the tumor was composed of spindle/short- spindle cells with clear cytoplasma, which were mixed with solid sheets or some tubular structures resembling Sertoli cell tumor. Less than 10% of the tumor showed typical morphology of endometrioid adenocarcinoma. Immunohistochemical staining demonstrated the tumor cells were diffusely positive for CK, CK7, EMA, ER, while negative for ot-inhibin, PLAP and CA125. Conclusions Morpho- logically, ESCSC is easily confused with ovarian sex-cord tumour. To carefully observe the mass, take enough tissue samples, seek the clue of classical endometrioid adenocareinoma and employ the necessary immunohistoehemical staining is very useful to reach a correct di~,nn^i~.

关 键 词：卵巢肿瘤 性索一间质细胞肿瘤 子宫内膜样腺癌 诊断 

分 类 号：R737.33[医药卫生—肿瘤]