DNA修复基因XRCC1、MGMT在胃癌中表达的研究  

Expression of XRCC1 and MGMT in gastric carcinoma

作　　者：方航荣[1] 郑建云[1] 刘冰[1] 李艳东[1] 王美妮[1] 

机构地区：[1]西安医学院附属医院病理科,陕西西安710077

出　　处：《现代肿瘤医学》2013年第2期377-380,共4页Journal of Modern Oncology

基　　金：西安医学院附属医院院级资助项目(编号:XYFY-09-18)

摘　　要：目的:探讨胃癌及正常胃组织中DNA修复基因XRCC1和MGMT的表达及其意义。方法:免疫组化法检测胃癌组织及正常胃组织中XRCC1和MGMT的蛋白表达情况。结果:胃癌组XRCC1蛋白的阳性表达率为86.25%明显高于正常胃组织的13.75%(P<0.05)。胃癌组MGMT蛋白的阳性表达率为33.75%,明显低于正常胃组织的66.25%(P<0.05)。二者在胃癌中的表达无明显相关关系。结论:XRCC1与MGMT基因在胃癌发生过程中可能起重要作用,两者在胃癌中表达无明显相关性,提示两者修复损伤途径相互独立。Objective：To investigate the protein expression and significance of repair gene XRCC1 and MGMT in gastric carcinoma and normal gastric tissue. Methods：Expressions of XRCC1 and MGMT protein were detected by immunohistochemical techniques in gastric carcinoma and normal gastric tissue. Results：The positive expression rate of XRCC 1 in gastric carcinoma was signififcanfly higher （86.25%） than normal gastric tissue（ 13.75% ）, The positive expression rate of MGMT in gastric carcinoma was signififcantly lower （33.75%） than normal gastric tissue （66.25%）. Tile cxpresshm of XRCCI and MGMT ill gastric carcinoma had no relashionship. Conclusion： XRCCI and MGMT gene may play important roles in careinogenesis and progression of gastric carcinoma,the expression of XRCC1 and MGMT is not related to each other.

关 键 词：胃癌 XRCC1 MGMT 

分 类 号：R735.2[医药卫生—肿瘤]