TF双周方案治疗晚期胃癌的临床疗效观察  

TF biweekly treatment of advanced gastric cancer

作　　者：马慧敏[1] 邹锦绣[1] 袁霞[1] 

机构地区：[1]惠州市中心人民医院肿瘤内科,广东惠州516000

出　　处：《现代肿瘤医学》2013年第2期380-382,共3页Journal of Modern Oncology

摘　　要：目的:评价紫杉醇联合亚叶酸钙、氟尿嘧啶双周疗法一线治疗晚期胃癌的临床疗效和耐受性。方法:46例初治IV期胃癌患者一线予TF方案化疗:紫杉醇100mg/m2d1,CF 400mg/m2iv d1,5-FU 400mg/m2bolus后2400mg/m2civ 46h,Q14d,4周期后评价疗效。结果:46例患者中,完全缓解0例(0%),部分缓解20例(43.5%),稳定18例(39.1%),进展8例(17.4%),有效率43.4%。中位无进展生存期(PFS)6.7个月,中位总生存期(OS)10.1个月,1年生存率26.1%(12/46),无治疗相关性死亡。主要毒副反应有中性粒细胞减少(18.1%)、外周神经系统病变(48.0%)、恶心呕吐(39.7%)和脱发(31.3%)、过敏反应(2.3%)。结论:TF方案一线治疗晚期胃癌疗效肯定,毒副反应轻微,值得临床进一步研究。Objective：To evaluate the efficacy and tolerability of paclitaxel plus leucovorin, fluorouracil biweek first -line treatment of advanced gastric cancer. Methods：All 46 patients with newly diagnosed gastric cancer with metastasis, to treat by chemotherapy with TF： paelitaxel 100mg/m^2 d1 , CF400mg/m^2 iv d1 , 5 - FU 400mg/m^2 bolus follow by 2400mg/m^2 civ46h, Q14d, then were evaluated after 4 times chemotherapy. Results： In 46 patients, there were complete response 0 （0%）, partial remission in 20 cases （ 43.4% ）, stable in 18 cases （ 39.1% ）, progress in 8 cases （ 17.3 % ） , efficiency 43.4 %. The median progression - free survival（PFS） 6.7 months, median overall survival （OS） 10.1 months,1 year survival rate was 26.1% （12/46） ,no treatment -related death. The main toxicities were neutropenia（ 18.1% ） , peripheral nervous system diseases （48.0%） , nausea and vomiting （ 39.7% ） and alopecia （ 31.3 % ）, allergic reactions （ 2.3 % ）. Conclusion： The regimen of TF is effective in first - line treatment of advanced gastric cancer,toxicity is mild.

关 键 词：晚期胃癌 姑息化疗 紫杉醇 亚叶酸钙 5-氟尿嘧啶 

分 类 号：R735.2[医药卫生—肿瘤]