多发性骨髓瘤患者血清胱抑素C和血清肌酐的水平分析  

Analysis of the levels of serum Cystain C and serum creatinine in patients with multiple myeloma

作　　者：王金行[1] 周雯雯[1] 满冬亮[1] 杨志东[1] 刘柏新[1] 宋鉴清[1] 

机构地区：[1]中国医科大学附属第一医院检验科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2013年第2期412-414,共3页Journal of Modern Oncology

基　　金：辽宁省教育厅科研项目计划(编号:201102291)

摘　　要：目的:探讨血清胱抑素C(Cys-C)和血清肌酐与多发性骨髓瘤的关系。方法:选择42例初发多发性骨髓瘤患者和40例健康体检者,分别测定其血清Cys-C、尿素(Urea)、肌酐(Scr)及β2-微球蛋白(β2-microglobulin,β2-MG)水平含量。结果:多发性骨髓瘤组血清Cys-C和β2-MG水平较对照组明显升高,差异有统计学意义(P<0.01);血清Scr水平较对照组明显升高(P<0.05)。多发性骨髓瘤患者Ⅲ期中Cys-C水平较Ⅰ期和Ⅱ期明显升高(P<0.01);Ⅲ期中Scr和β2-MG水平较Ⅰ期和Ⅱ期明显升高(P<0.05)。而Ⅰ期和Ⅱ期血清Cys-C、Scr和β2-MG水平之间没有明显差别,差异无统计学意义(P>0.05)。Cys-C与β2-MG呈正相关(r=0.474,P<0.05)。结论:Cys-C可以作为诊断多发性骨髓瘤患者肾功能损害的敏感内源性标志之一,而且优于Urea、Scr和β2-MG,在多发性骨髓瘤分期和判断预后中也有重要的临床意义。Objective：To explore the relationship between serum cystain c and serum ereatinine in multiple myelo- ma. Methods：To select 42 patients with multiple myeloma and 40 healthy subjects ,which and measure serum Cys - C, level of urea （ Urea）, creatinine （ Scr ） and β2 - microglobulin （ β2 - MG）. Results ： The levels of serum Cys - C and 62 - MG in multiple myeloma group were significantly higher than that in control group, which was statistically significant （P 〈 0.01 ） ;The level of serum Scr increased markedly（ P 〈 0.05 ） , the level of Cys -C in patients with muhiple myeloma III was significantly higher than that in stage I and II（ P 〈 0.01 ） ; so were the level of Scr and β2 - MG（ P 〈 0.05 ）. However there were no significant differences among the levels of Cys - C, Scr and β2 - MG in phase I and phase II patients（ P 〉 0.05 ）. Cys - C and β2 - MG had a positive correlation（ r = 0. 474 ,P 〈 0.05 ）. Conclusion ： Cys - C can be used as one of the sensitive endogenous hallmarks of the diagnosis of multiple myeloma patients with impaired renal function, and superior to Urea, Scr and β2 - MG in multiple myeloma also has important clinical significance in the prognosis.

关 键 词：多发性骨髓瘤 胱抑素C Β2-微球蛋白 尿素 血清肌酐 

分 类 号：R738.1[医药卫生—肿瘤]