超声微泡携靶向基因治疗肝癌的研究进展  

Ultrasonic microbubble-mediated targeted gene therapy for liver cancer

作　　者：李家乐[1] 周平[1] 刘浔阳[2] 

机构地区：[1]中南大学湘雅三医院超声科,湖南长沙410013 [2]中南大学湘雅三医院普通外科,湖南长沙410013

出　　处：《中国普通外科杂志》2013年第1期88-92,共5页China Journal of General Surgery

基　　金：国家自然科学基金面上资助项目(81271680)

摘　　要：目前肝癌是世界上最常见的恶性肿瘤之一,有着较高的发病率和病死率。随着超声造影技术与分子生物学的不断发展,超声微泡造影剂携带基因治疗肿瘤是当前的研究的热点,为肿瘤治疗带来了新的希望。超声靶向击破技术为肝癌基因治疗方面提供了一种强有效的非病毒途径,具有广泛的应用潜力。现将超声微泡联合基因靶向治疗肝癌的研究现状作一综述。At present, liver cancer is one of the most common malignant tumors worldwide with a high prevalence and mortality. With the development of technologies in ultrasound contrast agents and molecular biology, gene delivery using microbuble ultrasound contrast agents for the treatment of cancer has currently become a hot spot of investigation, which opens new perspectives for cancer therapy. Ultrasound-targeted microbubble destruction provides a potential. This paper target gene therapy for highly effective non-viral means for gene therapy of liver cancer with great application addresses the current status of investigation in the ultrasonic microbubble-mediated liver cancer.

关 键 词：肝肿瘤 超声靶向击破技术 基因疗法 微泡超声造影剂 综述文献 

分 类 号：R735.7[医药卫生—肿瘤]