乙型肝炎病毒男性携带者行IVF/ICSI治疗的结局分析  

Effect of HBV Seropositive in Male on the Process and Outcomes of IVF/ICSI Treatment

作　　者：陈华[1] 武新梅[1] 习海涛[1] 单丹[1] 管荷琴[1] 葛红山[1] 吕杰强[1] 

机构地区：[1]温州医学院附属第二医院,325027

出　　处：《医学研究杂志》2013年第1期145-147,共3页Journal of Medical Research

基　　金：浙江省教育厅基金资助项目(Y200907948)

摘　　要：目的研究男性乙型肝炎病毒(hepatitis B virus,HBV)感染对IVF/ICSI(in vitro fertilization or intracytoplasmic sperminjection)过程和周期结局的影响。方法 115对男方乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)阳性、女方阴性的夫妇作为实验组,对照组为夫妇双方HBsAg均阴性,根据HBV组女性年龄、月经第3天FSH值、体重指数和治疗方法(IVF或ICSI)按1∶2的比例进行配对,比较分析两组的FSH注射天数、Gn(gonadotropin)用量、HCG(human chorionic gonadotropin)日子宫内膜厚度和E2(estradiol)值、平均获卵数、成熟率、2PN(two pronucleus)受精率、卵裂率、优质胚胎率、临床妊娠率和种植率等参数。结果两组间各项指标均无统计学差异(P>0.05)。结论男性HBV感染不影响IVF/ICSI过程和周期结局。Objective To evaluate the possible influence of IVF/ICSI cycles on outcomes in Hepatitis B surface antigen（HBsAg） seropositive men and seronegative female partners. Methods Totally 115 IVF/ICSI cycles in couples with men HBV infection were compared with 230 cycles in non - infected couples, matched for female age, D3 serum FSH level, body mass index, type of infertility （ primary or secondary） , reasons for infertility and ART approach used（ IVF or ICSI）. Results Duration of FSH injection, total dosage of gonadotropin, serum estradiol level and endometrial thickness on the day of hCG injection and mean number oocytes retrieved were similar when compared to matched control. Rates of two- pronuclear, cleavaged embryos and proportion of viable embryos were comparable between the two groups. And there was no significant difference in ongoing pregnancy rate and implantation rate between seropositive women group and matched - control. Conclusion These datum indicate that men with HBV infection is unlikely to represent poor IVF/ICSI outcomes.

关 键 词：乙型肝炎 IVF ICSI 临床妊娠率 

分 类 号：R737.31[医药卫生—肿瘤]