硫化氢作用于钾通道产生的心血管效应  

Cardiovascular Effects of Hydrogen Sulfide on K^+ Channel

作　　者：胡恒境[1,2] 屈顺林[2] 谭小进[1] 姜志胜[2] 

机构地区：[1]南华大学附属第一医院心内科,湖南省衡阳市421001 [2]南华大学心血管病研究所动脉硬化学湖南省重点实验室,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2013年第2期182-186,共5页Chinese Journal of Arteriosclerosis

摘　　要：硫化氢是一种具有臭鸡蛋味道的有毒气体,但是近年来有大量文献报道硫化氢是继一氧化碳和一氧化氮之后的第三种气体信号分子。硫化氢主要在胱硫醚-γ-裂解酶、胱硫醚-β-合成酶、3-巯基丙酮酸硫转移酶作用下产生,具有舒张血管、调节血压、抑制血管平滑肌细胞增殖和低密度脂蛋白氧化修饰等功能,硫化氢对缺血的心肌细胞具有明显的保护效应,并且还能通过多种途径减轻心肌的损伤。有研究显示钾通道可能参与了多形式多器官的缺血保护。而硫化氢作为重要的气体信号分子,其舒张病变血管、提高血液灌注水平的效应可能与钾通道开放有关。本文主要就硫化氢作用于钾通道产生血管效应的机制做一简要综述。Hydrogen sulfide is a toxic gas with rotten eggs taste. However, there were a large number of articles reported that hydrogen sulfide was the third gaseous signaling molecule after CO and NO in recent years. Hydrogen sulfide derived mainly from cystathionine b-synthase, cystathionine c-lyase and 3-Mercaptopyruvate sulfurtransferase enzyme, which had many roles such as blood vessel dilatation, regulating blood pressure, inhibiting vascular smooth muscle cell pro- liferation and low density lipoprotein （LDL） oxidative modification. Especially hydrogen sulfide has a significant protec- tive role on ischemic myocardial cells. Studies have shown that the potassium channels may be involved in various forms and multiple organ ischemia protection. Hydrogen Sulfide is an important gaseous signaling molecule, of which improving blood perfusion levels may be related to the potassium channel. This review focuses on the role of potassium channel during the process of hydrogen sulfide producing biological effect.

关 键 词：硫化氢 ATP敏感性钾通道 钙通道激活性钾通道 内皮源性超极化因子 

分 类 号：R363[医药卫生—病理学]