脑梗死与2型糖尿病患者血清粒细胞集落刺激因子水平及意义  

Serum granulocyte colony-stimulating factor level and significance of cerebral infarction and type 2 diabetes patients

作　　者：赵鸿雁[1] 王宏[1] 王蓉[1] 段新辉[1] 徐超[1] 

机构地区：[1]新疆石河子大学医学院第一附属医院神经内科,新疆石河子832002

出　　处：《临床荟萃》2013年第2期134-137,共4页Clinical Focus

摘　　要：目的探讨脑梗死和2型糖尿病患者血清粒细胞集落刺激因子(G-CSF)水平及意义。方法共纳入观察对象120例,分4组:健康对照组、2型糖尿病组、脑梗死组、脑梗死合并2型糖尿病组,每组各30例。采用酶联免疫吸附法(ELISA)测定血清G-CSF水平:①比较4组间血清G-CSF水平;②将脑梗死患者60例根据美国国立卫生研究院卒中量表(NIHSS)评分中位数分为:A组(1～7分),B组(8～21分),每组各30例,比较两组患者血清G-CSF水平。结果①4组血清中G-CSF水平差异有统计学意义(P<0.01);健康对照组低于其他3组,(33.40±8.07)ng/L vs(43.84±8.36)ng/L、(50.92±6.12)ng/L、(50.98±6.24)ng/L(P<0.01);2型糖尿病组低于脑梗死组与脑梗死合并2型糖尿病组(P<0.01);脑梗死组与脑梗死合并2型糖尿病组比较差异无统计学意义(P>0.05);②脑梗死患者中B组血清G-CSF较A组明显升高,(54.05±4.15)ng/L vs(47.85±6.26)ng/L(P<0.01)。结论血清G-CSF参与了脑梗死和2型糖尿病的病理生理过程;脑梗死患者血清G-CSF水平与其早期神经功能缺损的严重程度密切相关。Objective To explore the serum granulocyte colony-stimulating factor （G-CSF） levels and significance in cerebral infarction patients and type 2 diabetes patients. Methods A total of 120 subjects were divided into four groups .. healthy control group, type 2 diabetes group, cerebral infarction group, cerebral infarction patients with type 2 diabetes group（each group, n = 30）. Serum G-CSF level was determined by enzyme-linked immunosorbent assay （ELISA）：①To compare serum G-CSF levels among four groups; ②The 60 patients with cerebral infarction were divided into two groups （each group, n =30） according to its National Institutes of Health Stroke Scale（NHISS） score median：group A （1 to 7 scores）,group B （8 to 21 scores ）. Then,serum G-CSF level was compared between the two groups. Results 1 There were significant difference in G-CSF among the four groups （ P 〈0.01） 2The serum G- GSF level of healthy control group was significantly lower than that of other three groups, （33.40±8.07） ng/L vs （43.84± 8.36） ng/L, （50.92±6. 12） ng/L, （50.98±6.24） ng/L（ P 〈0.01）;The serum G-CSF level of type 2 diabetes group was significantly lower than that of cerebral infarction group and cerebral infarction patients with type 2 diabetes group （ P 〈0.05） ;There was no significant difference between cerebral infarction group and cerebral infarction in patients with type 2 diabetes group（ P 〉0.05） ;②The serum G-CSF of group B was significantly higher than that of group A, （54.05 ± 4.15） ng/L vs （47.85 ± 6.26） ng/L （P 〈 0.01）. Conelusion Serum G-CSF involved in the pathophysiological process of cerebral infarction and type 2 diabetes;The serum G-CSF of cerebral infarction patients is closely related to the severity level of early neurological deficit.

关 键 词：脑梗塞 糖尿病 2型 粒细胞集落刺激因子 

分 类 号：R743[医药卫生—神经病学与精神病学]