环境内分泌干扰物引致儿童性发育异常的研究进展  

Research progress of environmental endocrine disruptors causing child sexual dysplasia

作　　者：蔡德培[1] 

机构地区：[1]复旦大学附属儿科医院,上海201102

出　　处：《上海医药》2013年第2期3-5,共3页Shanghai Medical & Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号 30371820)

摘　　要：当前,正常儿童较普遍地暴露于环境内分泌干扰 (environmental endocrine disruptors, EEDS),而 EEDs 与儿童性发育异常的发病有密切关系,是其重要的致病因素之一。这应引起政府足够重视,尽快完善相关产业及环保方面的政策法规,从源头上杜绝这些有害物质造成的环境污染 ;另一方面应积极制定适合国情的有效防治方案,包括采用药物进行治疗干预。已证实恰当的中药治疗方案对EEDs的拟雌激素活性具有显著的拮抗作用,中药可通过对靶器官上雌激素受体、雌激素合成酶及生长因子的调节作用,发挥其对 EEDs 拟雌激素活性的拮抗作用。At present, the normal children have extensively exposed to the pollution of environmental endocrine disruptors （ EEDs ）. There is a close relationship between EEDs and the onset of child sexual dysplasia, which is one of the important factors inducing the disease. It ought to attract the sufficient attention of the government to perfect the decrees and policy related to industries and environmental protection as quickly as possible so as to put an end of the environmental pollution from the sources of these pernicious materials. In addition, the effective preventive and therapeutic regimes which suit our national situation ought to be formulated, including therapeutic intervention with medicaments. It has been verified that the proper therapeutic regime of traditional Chinese herbal medicine （TCHM） could have antagonistic effect on the estrogen-like activity of EEDs obviously. The TCHM could exert antagonistic effect against the estrogen-like activity of EEDs via regulative effect to estrogen receptor, estrogen synthetase and growth factors on the target organs.

关 键 词：环境内分泌干扰物 性发育异常 中草药 

分 类 号：R725.8[医药卫生—儿科]