旋磁场对脑缺血再灌注损伤大鼠血液流变学的影响  

Effect of rotated magnetic field for hemorrheology of rats during the blood reperfusion after cerebral ischemia

作　　者：韩丽莎[1] 王维[2] 王芳[1] 韩利 

机构地区：[1]包头医学院,014010 [2]包头医学院第一附属医院 [3]包头市青山区防疫站

出　　处：《中华理疗杂志》2000年第3期155-157,共3页Chinese Journal of Physical Therapy

摘　　要：目的　对脑缺血再灌注损伤大鼠应用旋磁场后 ,观察超氧化物歧化酶 (SOD)、丙二醛(MDA)、前列环素 (PGI2 )、血栓素 (TXA2 )及血液流变学指标的变化。方法　实验动物分 3组 ,每组12只。对照组做假手术 ;再灌组 ,旋磁组双侧颈总动脉夹闭 30min ,再灌注 30min(旋磁组大鼠夹闭颈总动脉后置于旋磁场内 ,鼠体中心部分距磁极为 6cm ,磁感应强度为 30mT) ,腹主动脉取血进行观察。结果　旋磁组SOD活力和PGI2 水平分别为 ( 172 .5 3± 9.15 )NU/ml,( 80 1.88±12 2 .70 ) pg/ml,显著高于再灌组 ( 16 2 .34± 7.5 0 )NU/ml,( 5 48.0 8± 12 8.15 ) pg/ml(P <0 .0 5 ,<0 .0 1) ;MDA含量和TXA2 水平为 ( 7.74± 0 .94)nmol/ml,( 40 5 .2 3± 79.5 2 )pg/ml,显著低于再灌组 ( 9.19±1.43)nmol/ml,( 5 11.45± 10 2 .2 7) pg/ml(P <0 .0 5 ) ;同时 ,旋磁场可降低红细胞压积 ,使红细胞解聚 ,增加其变形能力。结论　旋磁场可通过降低自由基 ,调节TXA2 /PGI2 比值 ,降低血液粘稠度 ,改善血液循环状态 。Objective In order to study the effect of rotated magnetic field on Superoxide dismutase(SOD)、Malonyl dialdehyde(MDA)、Prostacylin(PGI 2)、Thromboxane A(TXA 2) and hemorrheology in rats during the blood reperfusion after cerebral ischemia.Methods 36 rats were equally divided into control group,reperfusion group and rotated magnetic group.Control group rats were taken false operation.Other two groups rats formed the cerebral ischemia from biliteral carotid occlusion by splint for 30 min,then relaxation 30 min to give reperfusion.The experimental rats were treated with rotated magnetic field on biliteral carotid areas 60 min at beginning of ischemia.Before and after the treatment,the hemorrheology and above biochemistry items in blood were observed.Results The SOD and PGI 2 level of rotated magnetic group was respectively (172.53±9.15)NU/ml and (801.88±122.70)pg/ml,the SOD and PGI 2 of reperfusion group was (162.34±7.50)NU/ml and (548.08±128.15)pg/ml.Comparison was made between two groups.The effect of rotated magnetic field group to SOD and PGI 2 was obviously superior to reperfusion group(P<0.05～0.01).After magnetic treatment,the MDA,TXA 2 and hemotocrit were reduced,the erythrocyte aggregation and deformability was also improved.Conclusion It is suggested that the rotated magnetic field may decrease free radicals,blood viscosity and regulate the ratio of TXA 2/PGI 2 to improve the blood circulation.It has a prophylaxis and treatment effect for treating the reperfusion damage after cerebral ischemia.

关 键 词：电磁场 脑缺血 血液流变学 再灌注损伤 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R454.1[医药卫生—临床医学]