精神分裂症患者健康后代糖代谢异常对照研究  

A control study of Glycometabolism abnormality between the healthy offspring of schizophrenic patients and Comparison

作　　者：王育红[1,2] 杨建立[3] 杨坤[3] 成爽[1,2] 谢玲银[1,2] 张智勇[1,2] 林永雄[1,2] 黄伟华[1,2] 吴雪娥[1,2] 

机构地区：[1]暨南大学附属清远医院 [2]清远市人民医院精神卫生中心,广东清远511518 [3]天津市精神卫生中心

出　　处：《中国民康医学》2013年第3期17-20,共4页Medical Journal of Chinese People’s Health

基　　金：国家自然科学青年基金(30900484);广东省清远市科技局计划项目(2010B92)资助

摘　　要：目的:探讨精神分裂症患者的健康后代糖代谢相关指标变化。方法:42名满足ICD-10精神分裂症诊断标准患者健康子女后代(平均年龄31.3岁)和年龄、性别相匹配的36名健康对照后代,空腹抽血后,同一时间检测血浆胰岛素水平、胰岛素抵抗、空腹血糖、口服葡萄糖耐量试验2 h血糖、糖化血红蛋白、瘦素等指标测定;并测量身高(kg)、体重(m)、腰围(cm)、臀围(cm)(体重指数(BMI)=体重(kg)/[身高(m)]2。结果:精神分裂症健康后代与对照组糖代谢相关指标相比,有较低胰岛素生长因子-I水平,较高血浆胰岛素水平、胰岛素抵抗、口服葡萄糖耐量试验2 h血糖水平、糖化血红蛋白;同时,空腹葡萄糖水平、瘦素及生长激素无统计学意义。结论:精神分裂症健康后代存在糖代谢相关指标异常,这间接支持糖代谢相关指标可能参与精神分裂症的病理生理机制之中。Objective：To explore the fasting plasma levels of glycometabolism related factors in healthy offspring of schizo- phrenic patients. Methods ：42 healthy offspring of schizophrenic inpatients which met ICD - 10 criteria for schizophrenia and 36 com- parison subjects were recruited. Fasting plasma levels of glucose, insulin, insulin resistance, impaired glucose tolerance （IGT）, GH- hA1C; Leptin,C peptide and eortisol were tested for all subjects. Results： Compared with the comparison subjects, offspring of schizo- phrenic patients had significantly lower means IGF - I, and higher mean plasma insulin and insulin resistance, mean plasma impaired glucose tolerance（ IGT）, GHbA1 C; and mean plasma cortisol level. Meanwhile, the mean fasting plasma levels of glucose, Leptin and GH had no significant differences between offspring of schizophrenic patients and healthy comparison subjects. Conclusions ： Offspring of schizophrenic patients existed abnormality of glycometabolism related factors. These data indirectly supported that abnormality of gly- cometabolism related factors may be potentially involved in the pathogenesis of schizophrenia.

关 键 词：糖代谢相关因子 健康后代 精神分裂症 病理生理 

分 类 号：R749.3[医药卫生—神经病学与精神病学]