自体髂骨复合PRF修复牙槽嵴裂的实验研究  

Experimental study on autologous iliac bone transplantation combined with PRF

作　　者：周龙[1] 封兴华[1] 陆斌[1] 

机构地区：[1]第四军医大学口腔医学院颌面整形外科,陕西西安710032

出　　处：《中国美容医学》2013年第1期24-27,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:将富血小板纤维蛋白(Pl at el et-ri ch fi bri n,PRF)应用于牙槽嵴裂植骨手术,验证其是否能够减少植骨术后的骨吸收。方法:8～12月龄犬8只,以外科手术的方法制备双侧牙槽嵴裂模型,随机于两侧同期植入自体髂骨(对照组)及自体髂骨混合PRF(实验组)。于术后当日、2个月、4个月时拍摄上颌骨CT,利用三维重建软件测量植骨区体积,计算骨吸收率。结果:术后2个月、4个月时实验组的骨吸收率明显小于对照组,行配对样本的t检验,P<0.01。结论:将PRF加入自体髂骨进行骨移植修复犬的牙槽嵴裂,在术后4个月的时间范围内,可以减少术后的骨吸收。Objective We grafted the platelet-rich fibrin （PRF） mixed with autogenous lilac bone in the alveolar cleft and evaluated the bone resorption after operation. Methods 8 dogs （8-12 months） were created bilateral alveolar cleft by surgical operation, autogenous lilac bone（control group） and the PRF mixed with autogenous lilac bone（PRF group） were implanted into the defect of one side randomly and bone regeneration was investigated 2 months and 4 months after implantation. Results The bone resorption of the PRF group was lower than that of the control group at 2 months and 4 months,P〈0.01. Conclusion Autogenous lilac bone grafting with PRF,which significantly reduces postoperative bone resorption on dog bilateral alveolar cleft model.

关 键 词：富血小板纤维蛋白 牙槽嵴裂植骨 三维重建 骨吸收率 

分 类 号：R782[医药卫生—口腔医学]