内源性一氧化氮在急性高原病中的研究进展  

Roles of endogenous nitric oxide in acute mountain sickness

作　　者：卞士柱[1] 黄岚[1] 

机构地区：[1]第三军医大学新桥医院心血管内科,全军心血管病研究所,重庆400037

出　　处：《中国病理生理杂志》2013年第1期174-178,共5页Chinese Journal of Pathophysiology

基　　金：国家卫生部卫生行业专项基金资助项目(No.201002012)

摘　　要：1一氧化氮（nitric oxide，NO）与内源性一氧化氮（endogenousNO，eNO） NO是具有调节血管张力、血流等众多生物学作用的脂溶性气体信号分子，eNO是由L-精氨酸（L-arginine，L-Arg）经过体内一氧化氮合酶[nitricoxide synthase，NOS；主要有神经源型（neuronalNOS，nNOS）、诱导型（inducibleNOS，iNOS）和内皮源型（endothelial NOS，eNOS）3种]催化合成的，广泛存在于全身组织。Acute mountain sickness （AMS） is the greatest challenge of military medicine and wilderness med- icine, as the increasing populations of entering Tibet and others who rapidly ascend to high altitude. AMS is considered as a kind of vascular dysfunction and disequilibrium of body fluid diseases induced by environmental stress. Studies reveal that endogenous nitric oxide （NO）, a predominant endogenous vessel dilator, plays a crucial role in the pathogenesis of AMS. The decreased production and blocked delivery of NO cause dysfunction of the vascular system in hypoxic situations. Subse- quently, AMS develops under the facilitations of alterations in brain and pulmonary blood vessels. NO or L - arginine （ the precursor of NO） can also be used to prevent and treat AMS. This review will summarize the progress on the roles of NO in the pathogenesis, pathophysiology, treatment and prophylaxis of AMS.

关 键 词：一氧化氮 急性高原病 

分 类 号：R363[医药卫生—病理学]