5695例孕中期唐氏综合征血清学筛查结果的分析  

Analysis on serological screening of Down's syndrome in 5 695 mid-pregnant women

作　　者：李红梅[1] 刘水和[2] 叶震璇[1] 张华[1] 陈肖[3] 

机构地区：[1]贵州省人民医院检验科,550002 [2]贵州省人民医院中心实验室,550002 [3]贵阳医学院,550004

出　　处：《国际检验医学杂志》2012年第15期1836-1838,共3页International Journal of Laboratory Medicine

摘　　要：目的通过分析5695例孕中期妇女的血清学筛查结果,探讨贵州地区孕中期妇女唐氏筛查的意义。方法对贵州地区孕14周～20+6周的孕妇进行产前血清AFP和总β-hCG浓度的检测,结合孕周、年龄、体质量等因素进行风险评估。对高风险者行羊水细胞染色体分析。结果 5695例孕妇筛查出唐氏综合征高风险249例,检出率4.37%;经染色体核型检查84例,确诊异常6例,阳性率7.14%。本次研究汉族唐氏综合征阳性率为4.1%(188/4663);少数民族为4.6%(47/1032),两者比较差异无统计学意义(P>0.05)。≥35岁的孕妇唐氏综合征阳性率(28.8%)明显高于年龄低于35岁的孕妇(5.1%),差异有统计学意义(P<0.05)。孕妇的孕周、体质量及年龄与血清AFP和总β-hCG浓度有相关性(P<0.01)。结论唐氏筛查的结果和孕妇的年龄、孕周、体质量及是否吸烟均有关系。因此要准确地收集患者的资料,以取得可靠的评估结果。Objective To analyze the antenatal screening for fetal congenital abnormality in 5 695 mid-pregnant women in certain region.Methods AFP and total β-HCG were tested in the serum of 5 695 mid-pregnant women with gestational age for 14-20＋6 weeks.Risk of Down＇s syndrome was assessed by integration of gestational weeks,age and bodyweight.And karyotype analysis of amniotic fluid cell was performed among high risk pregnant women.Results The detection rate of high risk of Down＇s syndrome were 4.37%（249/5 695）.6 fetus were diagnosed with Down＇s syndrome.The positive rate of Han case was 4.1%（188/4 663）,and that of minority was 4.6%（47/1 032）.There was no statistically significant difference（P0.05） between the two groups.Positive rate of Down＇s syndrome at least 35 years old pregnant women（28.8%） were significantly higher than that of pregnant women less than 35 years old（5.1%,P0.05）.Conclusion The accurate of the Down＇s syndrome might be correlated with pregnant women＇s age,gestational weeks,bodyweight and smoking.In order to obtain reliable risk assessment results,relevant data must be collected accurately.

关 键 词：唐氏综合征 产前诊断 甲胎蛋白类 绒毛膜促性腺激素 β亚单位 人 

分 类 号：R714.5[医药卫生—妇产科学]