贞芪扶正颗粒联合VADT方案治疗多发性骨髓瘤56例临床观察  

Clinical observation of multiple myeloma treated by combination of Zhenqi Fuzheng granule and VADT regimen

作　　者：张红柏[1] 耿慧[1] 焦晓云[1] 高世领[1] 闫晓婷[1] 张改茹[1] 

机构地区：[1]河北省民政总医院血液内科,河北邢台054000

出　　处：《河北中医》2012年第11期1693-1694,1753,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察贞芪扶正颗粒联合VADT方案治疗多发性骨髓瘤(MM)的临床疗效。方法将108例MM患者随机分为2组,治疗组56例予贞芪扶正颗粒联合VADT方案治疗,对照组52例单纯应用VADT方案治疗,每28 d为1个疗程,治疗4～6个疗程后观察2组疗效和心电图变化,检测心肌酶肌酸激酶同工酶(CK-MB)和心肌肌钙蛋白I(cTnI)的水平变化,肝功能丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST),血肌酐(Cr)、尿素氮(BUN)水平变化。结果治疗组总完全缓解(TR)率46.4%、总有效(RR)率85.7%,对照组TR率26.9%、RR率65.4%,治疗组TR率、RR率均高对照组(P<0.05),治疗组疗效优于对照组。治疗组心电图异常发生率7.1%,对照组心电图异常发生率30.8%,治疗组心电图异常发生率低于对照组(P<0.05),治疗组心电图疗效优于对照组。对照组治疗后CK-MB、cTnI、ALT、AST、Cr及BUN均较本组治疗前升高(P<0.05,P<0.01);治疗组治疗后CK-MB、cTnI、ALT、AST、Cr及BUN低于对照组(P<0.05),治疗组优于对照组。结论贞芪扶正颗粒联合VADT方案治疗MM,能明显提高MM的疗效,并能减轻心、肝、肾损害。Objective To observe clinical effect of multiple myeloma treated by combination of Zhenqi Fuzheng granule and VADT regimen.Methods 108 patients with multiple myeloma were randomly divided into two groups.56 cases in treatment group were treated by combination of Zhenqi Fuzheng granule and VADT regimen.52 cases in control group were treated by simple applications VADT regimen.The therapeutic course was 28 days.The effect and change of ECG was observed.The changes of levels of CK-MB,cTnI,ALT,AST,Cr and BUN were measured after 4～6 courses.Results The total remission rate and total effective rate was 46.4% and 85.7% in treatment group.The total remission rate and total effective rate was 26.9% and 65.4% in control group.The effect in treatment group was superior to that in control group.ECG abnormalities incidence rate in treatment group（7.1%） was lower than that in control group（30.8%,P〈0.05）.The levels of CK-MB,cTnI,ALT,AST,Cr and BUN in treatment group were lower than those in control group after treatment（P〈0.05）.Conclusion Zhenqi Fuzheng granule and VADT program can significantly improve the efficacy on the treatment of MM,and can reduce the damage of heart,liver and kidney.

关 键 词：多发性骨髓瘤 肿瘤 药物疗法 

分 类 号：R733.3[医药卫生—肿瘤] R453[医药卫生—临床医学]