溃疡性结肠炎患者血清MDA及SOD的变化  

Changes of serum MDA concentration and SOD activity in patients with ulcerative colitis

作　　者：郝志明[1] 苌新明[1] 王利公 

机构地区：[1]西安医科大学第一附属医院,西安710061

出　　处：《胃肠病学和肝病学杂志》2000年第2期124-125,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的　探讨氧自由基损伤与溃疡性结肠炎 (UC)发病之间的关系。方法　测定UC患者 (n =2 6 )血清中丙二醛 (MDA)浓度和超氧化物歧化酶 (SOD)活力 ,并与正常对照 (n =30 )比较。结果　正常对照 ,直肠乙状结肠炎 (n =15 )和病变超过乙状结肠者 (n =11)血清中MDA浓度依次升高 (分别为 3 85± 0 5 4,5 12± 0 6 5和 7 0 3± 0 82 μmoL/L) ,差异均有显著性 (P <0 0 5 ,P <0 0 2 ) ;而血清SOD活力依次下降 (分别为 113 72± 10 36 ,82 5 9± 11 87和 5 8 15± 10 33) ,差异均有显著性 (P <0 0 5 ,P <0 0 1)。结论 :氧自由基损伤是UC发病过程中的一个重要因素。Aim To Study the pathogenetic relationship between oxygen free radical(OFR) and ulcerative colitis.Methods Serum malondialdehyde(MDA) concentration and superoxide dismutase(SOD) activity were determined in 26 patients with UC and 30 controls.Results Serum MDA concentrations in patients with UC extending beyond the sigmoid(n=11),patients with rectitis sigmoiditis(n=15)and controls were 7.03±0 82,5 12±0 65 and 3.85±0 54 μmol/l,respectively.(7.03±0.82 vs 5.12±0.65, P <0 02;5 12±0 65 vs 3 85±0 54, P <0 05) Serum SOD activities in patients with UC extending beyond the sigmoid,patients with rectitis sigmoiditis and controls were 58.15±10 33,82 59±11 87 and 113.72±10.36NU/ml,respectively(58.15±0.33 vs 82.59±11.87, P <0 05;82 59±11 87 vs 113.72±10 36, P <0 01) Conclusions OFR plays an important role in the pathogenesis of UC,and the decrease of SOD activity is an important cause of OFR damage.

关 键 词：溃疡性结肠炎 游离基类 氧 SOD 

分 类 号：R574.620.2[医药卫生—消化系统]