小叶女贞叶片提取物药用活性研究  

Antibacterial,cytotoxic and antioxidant activity of leave extract from Ligustrum quihoui Carr

作　　者：倪建成[1,2] 吕述权[1,2] 丁骁[1,2] 谭庆伟[1,2] 

机构地区：[1]福建农林大学生物农药与化学生物学教育部重点实验室,福建福州350002 [2]福建农林大学植物病毒研究所,福建福州350002

出　　处：《武夷科学》2012年第1期128-132,共5页Wuyi Science Journal

基　　金：教育部博士点基金(20093515120005);福建省自然基金资助项目(2012J01088);福建省科技厅重点项目(2009N0016)

摘　　要：对小叶女贞叶片提取物进行体外抗菌、细胞毒性以及抗氧化药用活性研究,结果表明,小叶女贞叶片提取物对铜绿假单胞菌PAO1具有较强的抑制作用,最小抑制浓度(MIC)为8.0 mg/mL;对人肝癌细胞BEL-7404体外增殖具有显著的抑制作用,浓度在0.6 mg/mL时,抑制率达94.2%;同时具有较强的DPPH自由基清除能力,浓度为15.1μg/mL时,清除率为85.9%。活性跟踪测试表明,小叶女贞叶片提取物干柱层析得到的各组分中,低极性组分Fr.1为活性部分。The aqueous extract of Ligustrum quihoui leaves was tested for antibacterial,cytotoxic and antioxidant activities.The results indicated that the aqueous extract possessed a notable inhibitory effect toward Pseudomonas aeruginosa PAO1 with MIC 8.0 mg/mL.MTT assay showed that the aqueous extract presented significant inhibition on proliferation of human hepatocellular carcinoma cell BEL-7404,with an inhibitory rate of 94.2% at the concentration of 0.6 mg/mL.And the results of antioxidant activity showed that the aqueous extract exhibited strong scavenging capacity,with a DPPH clearance rate of 85.9% at the concentration of 15.1 g/mL.

关 键 词：小叶女贞 抑菌 细胞毒 抗氧化 

分 类 号：Q946.8[生物学—植物学] R282.71[医药卫生—中药学]