胃癌及癌前病变中表皮生长因子受体和P21^(ras)蛋白表达的研究  

EXPRESSION OF EPIDERMAL GROWTH FACTOR AND P21^(ras) RECEPTOR IN GASTRIC CARCINOMAAND PRECANCEROUS LESIONS

作　　者：兰春慧[1] 张小雨[2] 吴小翎[2] 

机构地区：[1]第三军医大学大坪医院野战外科研究所消化内科,重庆400042 [2]重庆医科大学第二临床学院消化内科

出　　处：《中国现代医学杂志》2000年第7期17-18,共2页China Journal of Modern Medicine

摘　　要：探讨表皮生长因子受体 (EGFR)和ras原癌基因产物—P2 1蛋白的表达与胃癌生物学行为的关系及其在胃癌发生发展中的作用。方法 :采用免疫组化S -P法。结果 :P2 1ras蛋白在慢性浅表性胃炎、异型增生、胃癌中阳性率分别为 10 % (2 /10 ) ,2 0 % (4 /2 0 ) ,52 .5% (2 1/4 0 ) ,差异有显著性 (P <0 .0 5)。EGFR在正常胃粘膜中均为阴性 ,EGFR在轻、中、重度异型增生的阳性率分别为 3 3 .3 % (3 /9) ,66.7% (4 /6) ,60 % (3 /5)。EGFR在早期和进展期胃癌中的阳性率分别为 2 0 % (2 /10 )和 60 % (18/3 0 ) ,进展期胃癌EGFR的阳性率显著高于早期胃癌 (P <0 .0 5)。结论 :P2 1ras蛋白、EGFR参与了胃癌的发生、发展 ,两者阳性的肿瘤可能具有更强的浸润与转移能力。objective: To study the expression and significance of EGFR and P21ras in the process of gastric carcinogensis. Methods: S-P immunohistochemical method was used to examine the expression of EGFR and P21ras in 80 cases (20 chronic superficial gastritis, 20 dysplasia, 40 gastric carcinomas). Results: The positive rates of P21ras in chronic superficial gastritis, dysplasia, gastric carcinoma were 10% (2/10), 20% (4/20), 52.5% (21/40) respectively (p<0.05). Normal gastric mucosa was negative for EGFR. Increased expression of EGFR was found in slight, moderate and severe dysplasia EGFR expression was 33.3% (3/9), 66.7% (4/6) and 60% (3/5). Statistically, the positive rates of EGFR in advanced gastric carcinomas were significantly higher than those in early gastric carcinomas (8% vs 22.2%, P<0.05. 83.3% vs 44.4%, P<0.05). Conclusions: P21ras and EGFR might play important roles in the process of carcinogenesis of gastric mucosa and be used as useful markers for the assessment of biological behavior of gastric carcinoma.

关 键 词：P21^RAS蛋白 胃肿瘤 癌前病变 免疫组化 EGFR 

分 类 号：R735.2[医药卫生—肿瘤]