P-700系列电极对猪室颤模型除颤效果的影响  

The influence of defibrillation electrodes of P-700 series on the defibrillation effect at pig ventruicular fibrillation model

作　　者：张真[1] 周正宇[1] 王禹斌[1] 周慧英[1] 王婧[1] 薛智谋[1] 

机构地区：[1]苏州大学医学部实验动物中心,江苏苏州215123

出　　处：《苏州大学学报（医学版）》2012年第6期778-782,共5页Suzhou University Journal of Medical Science

基　　金：江苏省自然科学基金资助项目(BK2010222);苏州市科技服务平台项目(SZP201001)

摘　　要：目的评价新型除颤电极片P-700系列除颤的有效性和安全性。方法通过心导管对3组不同体质量的太湖猪诱导,制作太湖猪室颤模型,根据"2010美国心脏协会心肺复苏及心血管急救指南"中的除颤能量适用范围为依据,以P-500系列电极片作为对照,用P-700系列电极片和P-500系列电极片分别进行体外除颤与复苏,统计除颤成功率,进行多普勒超声检查评价除颤前后各组动物的心脏功能,实验结束后做大体解剖并作病理分析。结果实验组和对照组的除颤成功率差异无统计学意义(P>0.05),3组动物除颤前后左室射血分数(EF)、左室舒缩面积变化率(FAC)、左心室收缩末期后壁厚度(LVPWS)的差异均无统计学意义(均P>0.05),病理学检查均未见明显异常。结论 P-700系列电极除颤成功率和安全性达到要求。Objective To evaluate the effect and safety of novel defibrillation electrode of P-700 series. Methods Cardiac catheter was used to induce and build ventrieular fibrillation model on three different weight groups of Tai-hu pigs, according to the available energy in ＂The 2010 AHA Guidelines for CPR and ECC＂, with P-500 series electrodes as control, Electrodes of P-700 and P-500 were utilized to do external defibrillate and resuscitation in vitro separately. The rate of successful defibrillation were recorded and Doppler ultrasound measurement were applied to evaluate the animals＇ myocardial function before and after defibrillation, Gross anatomy and pathological examination were performed after experiments. Results There was no obvious significance difference between the control groups and experimental groups on the rate of successful defibrillation （P 〉 0.05 ）. Among the three groups, there was no obvious significance difference prior to and after experiment on left ventricular ejection fraction, fraction area change and left ventricular end-systolic thickness （ all P 〉 0.05 ）. No obvious abnormal appearance was found in gross anatomy and pathological examination. Conclusion The efficacy and safety of P-700 series electrodes meet the standard.

关 键 词：电极片 除颤 心肺复苏 

分 类 号：R541.705[医药卫生—心血管疾病]