肺癌患者血浆和组织环核苷酸水平  

PLASMA AND TISSUE CYCLIC NUCIEOTIDES IN PATIENTS WITH PULMONARY NEOPLASM

作　　者：赵学海[1] 关钧[1] 夏俊[1] 秦秋月 

机构地区：[1]蚌埠医学院分子生物学研究室

出　　处：《蚌埠医学院学报》1991年第2期121-125,共5页Journal of Bengbu Medical College

摘　　要：用双抗体放射免疫测定法检测了24例肺癌、12例良性肺部疾患和6例经放疗或化疗后的肺癌患者血浆环核苷酸含量及8例肺癌组织中环核苷酸含量。发现肺瘤组血浆cGMP含量显著高于良性肺部疾患者,而cAMP/cGMP比率则明显降低;治疗组血浆cGMP含量明显下降,而cAMP/cGMP比率则显著上升;肺差分化癌组和肺鳞状细胞癌组的血浆环核苷酸含量无明显差异;肺癌组织中cAMP含量和cAMP/cGMP比率均明显下降,与正常组织中的含量有显著差异。Plasma cyclic nucleotides were measured by double antibodies radioimmunoassay in 24 pulmonary neoplasm, 32 benign lung diseases and 6 pulmonary neoplasm after radiotherapy or chemotherapy andin cancerous tissues per se from 8 patients with pulmonary neoplasm. The data obtained show that the level of plasma cGMP was significantly highet in the patients with pulmonary neoplasm than that with benign lung diseases, whereas the cAMP/cGMP ratio was considerably lower; in the therapeutic group the level of plasma cGMP decreased sharply, while the cAMP/cGMP ratio markedly increased; no significant difference was observed in cyclic nucleotides between in-different pulmonary neoplasms and squamous cell carcinomas of lung; the level of cAMP and cAMP/cGMP ratio in the tissues from patients with pulmonary neoplasm showed an obvious decline and there was a noticeable difference between cancerous tissue and normal tissue

关 键 词：肺肿瘤 环核苷酸 核射免疫测定 

分 类 号：R734.202[医药卫生—肿瘤]