太原地区HPV感染基因型分布与不同年龄段的相关性研究  

The relationship between sub-type HPV infection and different age groups in Taiyuan region

作　　者：罗慧琴[1] 王志刚[2] 李玲[1] 刘付芹[1] 

机构地区：[1]解放军第264医院检验科,山西太原030001 [2]海军出版社医疗所,天津300450

出　　处：《国际检验医学杂志》2012年第21期2602-2603,2605,共3页International Journal of Laboratory Medicine

摘　　要：目的分析太原地区不同年龄段妇女人乳头瘤病毒(HPV)感染状况及基因型分布特点。方法利用导流杂交基因芯片技术,对901例妇女阴道分泌物进行HPV分型检测,并对检测结果进行相关性分析。结果 901例标本中HPV阳性检出率为41.73%,其中单一感染、2型感染、多型感染的感染率分别为67.55%、21.28%、11.17%。HPV感染者中检出率较高的亚型为16型(10.54%)、6型(6.33%)、11型(5.44%)、52型(5.22%)和58型(4.33%);16～24岁、25～34岁、35～44岁、45～54岁、≥55岁各年龄段人群中HPV感染率分别57.43%、42.60%、35.45%、31.25%、51.56%,差异有统计学意义(χ2=31.94,P<0.05)。结论太原地区HPV感染以单一感染为主,与年龄分布具有相关性。Objective To investigate the relationship between sub-type HPV infection and different age groups in Taiyuan re gion. Methods The status of HPV infection in 901 patients were examined by flow through hybridization and genechip technique, The various sub-types of HPV were analyzed with statistical. Results HPV infection rate of the 901 patients was 41.73%. Among them, 67.55 % were infected by single H PV genotype, 21.28 % were infected by two genotypes and 11.17% were infected by three genotypes. In the positive rates of HPV, The percentages of 16,6,11,52,58, were 10.54 %, 6.33 %, 5.44%, 5.22 %, 4.33 % respec- tively;For different age groups （ 16 -- 24,25 -- 34,35 -- 44,45 -- 54, ≥ 55）, The age-specific prevalence of HPV was 57. 43 %, 42.60 %, 35.45 %, 31.25 %, 51.56 % respectively. Statistics difference was noted between these cases （ X2 = 31.94, P〈0.05）. Con- clusion HPV infection situation was comparatively severe and mostly were single infection in the Taiyuan area,age certainly had something to do with HPV infection.

关 键 词：人乳头瘤病毒 核酸杂交 基因型 年龄 

分 类 号：R737.33[医药卫生—肿瘤]