皮肤源祖细胞在再生医学中的作用  

Application of skin-derived precursors in the regenerative medicine

作　　者：杨眉[1,2] 柯亭羽[1] 毛铎[2] 孔德领[2] 车永哲[2] 徐勉[1] 

机构地区：[1]昆明医科大学第二附属医院老年内分泌科,云南省昆明市650101 [2]南开大学生物活性材料教育部重点实验室,天津市300071

出　　处：《中国组织工程研究》2012年第49期9283-9288,共6页Chinese Journal of Tissue Engineering Research

基　　金：云南省科技厅-昆明医学院联合专项基金(2008CD029);云南省教育厅科学研究基金项目(2009Y0167);国家自然科学基金面上项目(31260223;81260229;30970746)~~

摘　　要：背景:皮肤源祖细胞是存在于哺乳动物真皮层中的一种新型多能祖细胞。近年来,皮肤源祖细胞在再生医学中的研究及应用都有了很大进展。目的:对皮肤源祖细胞的研究现状及新进展作一综述。方法:应用计算机检索CNKI和PubMed数据库中1998年1月至2011年12月关于皮肤源祖细胞的文章,在标题和摘要中以"皮肤源祖细胞,毛囊干细胞,再生医学,组织工程"或"skin-derived precursor,hair-follicle,stem cells,neurons,schwann cells,smooth muscle cells,insulin-producing cells,bone repair,regenerative medicine,tissue engineering"为检索词进行检索。最终选择关于皮肤源祖细胞研究现状及应用前景的35篇文献进行综述。结果与结论:皮肤源祖细胞作为一种容易获得、具有多谱系分化潜能、易扩增、使用较为安全的成体干细胞,在神经损伤的治疗及神经再生、组织工程皮肤及人造血管的构建、胰岛替代治疗、造血系统重建、促进骨折愈合等方面均显示了较大的应用潜能及优势,在再生医学及组织工程研究中将成为一种重要的种子细胞。BACKGROUND： Skin-derived precursors are the new kind of multipotent progenitor cells that derived from the dermis Recently, great progress has been made in studies and applications about skin-derived precursors. OBJECTIVE： To summarize the research progress in skin-derived precursors. METHODS： Articles related to skin-derived precursors were retrieved in CNKI database and PubMed database （1998 01/2011 12）. The key words are ＂skin-derived precursor, hair-follicle, stem cells, neurons, schwann cells, smooth muscle cells, insulin-producing cells, bone repair, regenerative medicine, tissue engineering＂ in English and ＂skin-derived precursor, hair-follicle stem cells, regenerative medicine, tissue engineering＂ in Chinese. A total of 35 articles describing research progress in skin-derived precursors were obtained for the review. RESULTS AND CONCLUSION： Skin-derived precursors as a kind of adult stem cells have been widely used in nerve damage treatment and neural regeneration, construction of tissue-engineered skin and vascular prosthesis, replacement therapy of pancreatic islet, reconstruction of hematopoietic system and promotion of fracture healing due to their advantages including ease to access, multi-lineage differentiation potential, easy amplification and relatively safe. Skin-derived precursors are a source of seed cells for regenerative medicine and tissue engineering research.

关 键 词：皮肤源祖细胞 毛囊 干细胞 神经元 许旺细胞 平滑肌细胞 胰岛 胰岛素分泌细胞 骨骼修复 再生医学 组织工程 

分 类 号：R394.2[医药卫生—医学遗传学]