STin2基因多态性与偏头痛关联性研究  

Investigation of polymorphism of serotonin transporter gene(STin2)in migraine

作　　者：代亚美[1] 关珂[2] 程阅凤[2] 孔晓光[1] 邢燕[1] 赵知明[1] 潘尚哈[3] 李莹[4] 

机构地区：[1]哈尔滨医科大学第一临床医学院体检中心,黑龙江哈尔滨150001 [2]哈尔滨医科大学第一临床医学院神经内科,黑龙江哈尔滨150001 [3]哈尔滨医科大学第一临床医学院中心实验室,黑龙江哈尔滨150001 [4]通辽市医院神经内科,内蒙古通辽928000

出　　处：《中风与神经疾病杂志》2013年第1期28-31,共4页Journal of Apoplexy and Nervous Diseases

基　　金：黑龙江省教育厅科学技术研究项目(11551209)

摘　　要：目的探讨中国东北地区汉族人群中5-羟色胺转运体基因STin2多态性与偏头痛遗传易感性关系。方法研究对象包括150例偏头痛患者(其中无先兆偏头痛MO 111例,有先兆偏头痛MA 39例)及105例正常对照。详细记录临床资料,提取DNA。运用多聚酶链式反应和电泳分析技术,检测偏头痛组及对照组STin2基因多态性,并比较两组基因型及等位基因频率。结果偏头痛组STin2基因型总体分布与对照组相比无显著性差异(χ2=5.509,df=2,P=0.064),但MO患者STin2.12/12基因型频率为45.9%,对照组为31.4%,两者比较有统计学意义(χ2=4.785,df=1,P=0.036),STin2.9等位基因在MA患者中有增加的趋势(MA组为5.1%,而对照组为0.9%)。结论 STin2.12/12基因型可能增加偏头痛发病风险。Objective To investigate the susceptibility of serotonin transporter gene （STin2） polymorphism in mi- graine patients of Han nationality of North-east part of China. Methods Migraineurs, including 111 patients of migraine without aura（MO） and 39 patients of migraine with aura（MA） ,and 105 controls were included in this study after informed consent. Clinical histories were carefully recorded. Genomic DNA was extracted from blood of the patients and controls. U- sing a polymerase chain reaction based technique, polymorpbism of STin2 was determined in this migraineurs and control subjects,and the allelic and genotypic distributions in two groups were compared. Results Although the overall genotype distribution in migraine and control did not reached significance, the MO group had an over-representation of genotypes with two twelve repeat alleles （ STin2.12/12 ）45.9% compared to controls 31.4%. The MA group in STin2.9 carriers was 5.1% compared to 0.9% in the controls. Conclusion The findings support that the presence of two twelve repeat alleles （STin2.12/12） may increase the risk for migraine.

关 键 词：偏头痛 基因多态性 5-羟色胺转运体 

分 类 号：R747.2[医药卫生—神经病学与精神病学]