山楂醇提物灌胃对辐射损伤小鼠造血系统的保护作用  

Protection of the gastric lavage of Hawthorn alcohol extract on radiation injury in mice hematopoietic system

作　　者：秦继勇[1,2] 李文辉[1,2] 徐进彦[1,2] 刘建波[1,2] 王曙光 王承红[1,2] 常莉[1,2] 

机构地区：[1]昆明医科大学第三附属医院(云南省肿瘤医院)肿瘤放射治疗中心,昆明650118 [2]云南省肿瘤研究所肿瘤放射治疗研究中心,昆明650118 [3]云南省中医药研究所,昆明650118

出　　处：《中国中医基础医学杂志》2013年第1期54-57,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：云南省自然科学基金资助项目(2003C0008R)

摘　　要：目的:研究山楂醇提物灌胃对辐射损伤小鼠造血系统的保护作用。方法:实验组以不同剂量山楂醇提物给小鼠灌胃,单纯照射组(IR组)灌相应量生理盐水,灌胃5d后全组小鼠均接受6Gy的X射线一次全身照射,持续灌胃到第12、18天分别测定体重,静脉血RBC、WBC、PLT、Hb含量,骨髓有核细胞数、骨髓DNA含量。结果:不同剂量的山楂醇提物组与IR组比较,各给药+照射组的体重、血红蛋白、骨髓DNA含量、骨髓有核细胞数明显升高,2组存在统计学差异(P<0.05),其中均以HD(高剂量)+IR组升高最为明显。结论:山楂醇提物中的活性成分对辐射损伤小鼠的血红蛋白、骨髓有较明显保护作用。Objective： To investigate the radioprotective effects of the ethanol extract from Crataegus by intragastric administration on hcmatopoietic system of mice from radiation injury. Methods： Experimental groups received intragastric administration of drugs at different doses, and Irradiation fIR） group was administratered with the same amount of Normal Saline. After intragastric administration for 5 days, all mice were irradiated with 6 Gy of x-ray. Then the intragastric administration were followed for up to 12 days. At day 18, mice body weights, RBC, WBC, PLT and Hb contents from venous blood, the number of mouse bone marrow nucleated cells and bone marrow DNA contents were measured. Results： Compared with IR group, body weights, Hb contents and bone marrow DNA contents in experimental groups were significantly increased （P 〈 0.05） , especially in High dose ＋ irradiation （ HD ＋ IR） group. Conclusion： The active ingredient of the ethanol extract from Crataegus has radioprotective effects on Hb and bone marrow of mice obviously.

关 键 词：山楂 灌胃 造血系统 辐射损伤 保护作用 

分 类 号：R285.5[医药卫生—中药学]