艾司西酞普兰合并身心语法程序治疗对躯体形式障碍患者认知功能的影响  

Effect of escitalopram combined neuro-linguistic programming treatment on cognitive function in patients with somatoform disorders

作　　者：谢国军[1] 徐彩霞[1] 李晓玲[1] 罗伟森[1] 赵长江[1] 黎雪松[1] 

机构地区：[1]佛山市第三人民医院,佛山528041

出　　处：《中华行为医学与脑科学杂志》2013年第1期31-33,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：广东省医学科研基金项目（A2010603）

摘　　要：目的探讨艾司西酞普兰合并身心语法程序（NLP）治疗对躯体形式障碍患者认知功能的影响。方法120例躯体形式障碍患者被随机分为艾司西酞普兰治疗组（单药组）和艾司西酞普兰与NLP合并治疗组（合并组），每组60例，疗程6周，在基线及治疗6周后分别使用90项症状清单和功能大体评定量表评估疗效，使用瑞文标准推理测验、成人韦氏智力测验中的数字广度与数字符号测验评定认知功能，并同时进行事件相关电位P300检测。正常健康者60例作为对照。结果躯体形式障碍患者的瑞文分数、数字广度、数字符号得分均低于对照组（P〈0．01），N1、P3潜伏期长于对照组（P〈0．01或〈0．05），N1N2、N2P2、P2P3波幅小于对照组（均P=0．00）；治疗后单药组和合并组两组的瑞文分数[（91．25±14．87）分，（95．60±19．95）分]、数字广度得分[（11．98±1．89）分，（10．90±2．76）分]、数字符号得分[（11．71±2．89）分，（11．92±2．90）分]、N2P2波幅[（11．32±6．67）μV，（13．39±9．31）μV]、P2P3波幅[（9．04±6．14）μV，（9．51±7．17）μV]增加、N2潜伏期[（240．60±41．41）ms，（238．31±41．47）ms]延长，N1潜伏期缩短（P〈0．05或0．01）；单药组与合并组治疗前后比较，在数字广度、P2潜伏期、N1N2、N2P2、P2P3波幅方面差异有统计学意义（P〈0．05或0．01）。结论艾司西酞普兰单药治疗及艾司西酞普兰合并NLP治疗对躯体形式障碍患者的认知功能均有改善作用，其中合并治疗的优势更加突出。Objective To investigate the effect of escitalopram combined neuro-linguistic programming treatment（NLP） on cognitive function in patients with somatoform disorders. Methods 120 cases with somatoform disorders were randomly divided into the escitalopram monotherapy group and escitalopram with NLP combined group, with 60 cases in each group for six weeks. At baseline and after six weeks for treatment, it was respectively assessed that the efficacy using Symptom Checklist 90 and Global Assessment Function, and cognitive function using the Raven Standard Progressive Matrices Test, digit span and digit symbol tests in Adult Wechsler Intelligence Test, while event related potentials P300 were detected. 60 cases normal healthy adults as controls. Results Compared with the control group, the Raven scores, digit span, digit symbol scores were lower （P 〈 0. O1 ）, N1, P3 latent periods were longer （P 〈 0.01 or 〈 0.05 ）, N1N2, N2P2, P2P3 amplitudes were less （P = 0.00） in patients with somatoform disorders. After treatment, Raven scores （91.25 ± 14.87,95.60 ±19.95 ）, digit span scores（ 11.98 ±1.89,10.90 22.76） , digit symbol scores（ 11.71 22.89,11.92±2.90）, N2P2 amplitudes （ （ 11.32± 6.67） pN, （ 13.39 ± 9.31 ） μV）, P2P3 amplitudes （ （9.04 ± 6.14 ） μV, （9.51± 7.17 ） μV） increased, N2 latent periods （ （240.60 ± 41.41 ） ms, （238.31 ± 41.47 ） ms） prolonged, N1 latent periods shortened （ P〈0.05 or 0.01 ） in the monotherapy group and the combined group. The digit span, P2 latent periods, N1N2, N2P2, P2P3 amplitudes had statistically significant differences between monotherapy group and combined group after treatment （ P 〈 0.05 or 0.01 ）. Conclusion Both escitalopram monotherapy and escitalopram combined NLP have improved cognitive function in patients with somatoform disorders, but combined therapy has more prominent advantage.

关 键 词：艾司西酞普兰 身心语法程序学 躯体形式障碍 认知功能 

分 类 号：R74[医药卫生—神经病学与精神病学]