SPECT、PET神经受体和转运体显像技术在海洛因成瘾研究中的应用  

Neuroreceptor and its transporters imaging by PET and SPECT in heroin addiction

作　　者：袁杰[1] 刘兴党[1] 韩梅[2] 

机构地区：[1]复旦大学附属华山医院核医学科,上海200040 [2]北京师范大学化学学院,100875

出　　处：《国际放射医学核医学杂志》2013年第1期30-33,41,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家科技支撑计划（2008BA149804）

摘　　要：海洛因滥用导致了严重的社会、经济和健康问题。目前对海洛因成瘾机制的研究有了一定的进展，但是其神经递质、受体机制仍不清楚。该文综述了海洛因成瘾的潜在神经生物学机制及SPECT、PET神经受体和转运体显像技术在海洛因成瘾研究中的应用。Heroin abuse can cause prominent hazardous effects, including the collapse of social, economic status and health. The research of heroin addiction mechanism has got some progress, but the neurotransmitter and receptor mechanism are still not clear. This review discussed potential neurobiology mechanisms of heroin addiction, including opioid receptor, dopamine receptors and dopamine transporters in different brain areas when exposed to heroin and the application of PET and SPECT imaging of neuroreceptor and its transporters in heroin addiction research.

关 键 词：海洛因依赖 阿片样 受体 多巴胺 体层摄影术 发射型计算机 单光子 正电子发射断层显像术 

分 类 号：R74[医药卫生—神经病学与精神病学]