利培酮微球治疗精神分裂症疗效的临床对照研究  

Clinical Controlled Study on the Effect of Risperidone Microsphere on Schizophrenia

作　　者：秦国兴[1] 甘建光 田国强[1] 

机构地区：[1]浙江省绍兴市第七人民医院,312000

出　　处：《中国全科医学》2013年第3期308-309,320,共3页Chinese General Practice

摘　　要：目的探讨利培酮微球治疗精神分裂症的疗效与安全性。方法选取2007年1月—2009年9月我院就诊的精神分裂症患者35例为试验组,同时选择与试验组诊断相同、性别相同、年龄差异≤5岁,阳性与阴性症状量表(PANSS)评分差异≤5分的患者35例为对照组。试验组给予注射用长效利培酮微球25.0 mg或37.5 mg肌肉注射,1次/2周;对照组给予利培酮片1 mg,口服,2次/d,1周内逐步加至3～6 mg/d。观察2组用药剂量、治疗前后PAN-SS评分、有效率及不良事件发生情况。结果 2、4、6个月时试验组注射用长效利培酮微球平均剂量分别为(31.2±7.0)mg/2周、(33.8±6.6)mg/2周、(30.2±7.0)mg/2周;对照组利培酮片平均剂量分别为(4.5±1.0)mg/d、(4.1±0.8)mg/d、(4.1±0.9)mg/d。试验组与对照组患者治疗前后不同时间PANSS评分比较,差异有统计学意义(F时间=53.34,P<0.01);而两组间PANSS评分比较差异无统计学意义(F组间=0.54,P>0.05);试验组和对照组患者治疗前与治疗2、4、6个月时比较,差异均有统计学意义(P<0.01)。治疗6个月后,试验组有效31例,有效率为91.2%,无一例复发;对照组有效29例,复发2例,有效率为85.3%,两组有效率比较差异无统计学意义(χ2=0.142,P=0.707)。试验组16例(47.1%)发生不良事件,对照组22例(64.7%)发生不良事件,两组不良事件发生率比较差异无统计学意义(χ2=2.15,P>0.05)。结论注射用长效利培酮微球与利培酮片有同等的疗效和安全性,由于长效抗精神病药针剂具有的强制性等先天优点,可以作为精神分裂症维持治疗的一种良好选择。Objective To investigate clinical efficacy and safety of risperidone microspheres in the treatment of schizophrenia. Methods 35 cases of schizophrenic admitted to our hospital from January 2007 to September 2009 were selected as experiment group,while another 35 patients with the same diagnosis,same sex,age differences≤5 and PANSS score differences≤5 were selected as control group.The experiment group was given long-acting injection of 25.0 mg or 37.5 mg risperidone microspheres by intramuscular injection once every two weeks.While the control group was given 1 mg risperidone tablets two times a day per os,and the amount was increased to 3～6 mg/d within one week.The dosage,PANSS score,efficiency and adverse events were observed in the two groups. Results The average dose of long-acting risperidone injection microsphere in the 2nd,4th,and 6th month was respectively（31.2 ±7.0） mg/2 weeks,（33.8 ±6.6）mg/2 weeks,（30.2±7.0） mg/2 weeks and the average dose of risperidone tablets in control group was（4.5 ±1.0） mg/d,（4.1 ±0.8） mg/d,（4.1±0.9） mg/d.The PANSS scores at different times before and after treatment in the two groups showed statistically significant differences（Ftime=53.34,P0.01;Fintraclass=0.54,P0.05）.The PANSS scores before treatment in both the two groups showed statistically significant differences compared with those in the 2nd,4th and 6th month after treatment（P0.01）.Six months after treatment,31 cases in the experiment group were effective,with an effective rate of 91.2%,and no case relapsed.29 cases in the control group were effective,2 cases relapsed,with an effective rate of 85.3%.The difference of effective rate between the two groups was not statistically significant（χ2=0.142,P=0.707）.16 cases（47.1%） in the experiment group had adverse events while 22 cases（64.7%） in the control group had adverse events,and the difference was no statistically significant（χ2=2.15,P0.05）. Conclusion Injections of long-acting risperidone microsphere and risper

关 键 词：利培酮微球 精神分裂症 治疗结果 

分 类 号：R749.3[医药卫生—神经病学与精神病学]