脑出血并应激性溃疡患者血浆Ghrelin的变化及意义  

Changes of the level of Ghrelin in plasma and their significances in patients with cerebral hemorrhage and stress ulcers

作　　者：刘英[1] 杜业亮[2] 窦雯[1] 李增芬[2] 

机构地区：[1]潍坊医学院,潍坊261021 [2]山东潍坊市人民医院分院脑科医院神经内科,潍坊261021

出　　处：《中国实用神经疾病杂志》2013年第1期21-23,共3页Chinese Journal of Practical Nervous Diseases

基　　金：山东省潍坊市卫生局科技发展项目(201102018)

摘　　要：目的探讨脑出血并应激性溃疡患者血浆Ghrelin水平的变化,并分析其意义。方法收集的急性脑出血病例97例作为观察组,将其分为单纯脑出血组53例,脑出血并溃疡组44例(其中基底节42例,小脑7例,脑干12例,丘脑2例,破入脑室18例,脑叶16例),同时取30例健康体格检查者作为对照组。分别取观察组患者入院后24h内血浆,检测Ghrelin含量,进一步分析血浆Ghrelin含量、脑出血及应激性溃疡的关系。结果单纯脑出血组血浆Ghrelin水平为(166.50±74.79)μg/L,脑出血并应激性溃疡组血浆Ghrelin水平为(322.50±22.53)μg/L,对照组为(68.64±16.28)μg/L,3组比较差异有统计学意义(P<0.05)。结论急性脑出血患者血浆Ghrelin水平对诊断应激性溃疡及估计病情预后有一定提示作用。Objective To explore the changes of Ghrelin in plasma and its significance in cerebral hemorrhage and stress ulcer patients. Methods Totally 97 cases were divided into pure cerebral hemorrhage group （93 cases） and cerebral hemorrhage and stress ulcer group （44 cases）. At the same time, 30 cases of health examination people were taken as control group. The plasma specimens were taken in the research group alter admission day, the levels of Ghrelin of the three groups were compared, the relationship between Ghrelin in plasma and cere- bral hemorrhage and stress ulcer was analyzed. Results The level of Ghrelin in plasma of pure cerebral hemorrhage group was （166.50±74.79）μg/L, which of cerebral hemorrhage and stress ulcer group was （322.50±22.53）μg/L, and control group was （68.64±16.28）μg/L. There was significant difference among the three groups（P〈0.05）. Conehlsion The level of Ghrelin in plasma in cerebral hemorrhage patients can not only help to di- agnosis stress ulcer, but also estimate prognosis.

关 键 词：脑出血 应激 应激性溃疡 GHRELIN 

分 类 号：R743.34[医药卫生—神经病学与精神病学]