不同剂量阿司匹林在急性脑梗死治疗中的疗效比较  

Effect comparison of different doses of aspirin in the treatment for acute cerebral infarction

作　　者：林海[1] 高晓艳[1] 赵希海[1] 孙平[1] 吴艳军[1] 

机构地区：[1]大庆油田总医院集团脑血管医院,黑龙江大庆163113

出　　处：《中国当代医药》2013年第3期66-67,69,共3页China Modern Medicine

摘　　要：目的探讨不同剂量阿司匹林在急性脑梗死治疗中的临床效果。方法选取本院2011年1月～2012年8月收治的急性脑梗死患者126例,随机分为两组。63例患者于清晨空腹口服小剂量阿司匹林(100mg/次、1次/d、疗程4周)为对照组,63例患者于清晨空腹口服大剂量阿司匹林(300mg/次、1次/d、疗程4周)为观察组,比较两组患者的临床指标、临床疗效、神经功能缺损评分、不良反应情况。结果治疗后,观察组与对照组C反应蛋白浓度、神经功能缺损评分均明显下降,观察组C反应蛋白浓度、神经功能缺损评分均明显低于对照组,差异均有统计学意义(P<0.05)。观察组总有效率(71.4%)高于对照组(60.3%),观察组不良反应发生率(7.9%)高于对照组(4.8%),差异均无统计学意义(P>0.05)。结论在急性脑梗死治疗中,大剂量阿司匹林(300mg/d)的疗效好于小剂量(100mg/d),临床指标可得到明显改善,且无严重不良反应,值得临床推广使用。Objective To investigate the clinical effect of different doses of aspirin in the treatment for acute cerebral infarction. Methods One hundred and twenty-six patients with acute cerebral infarction were selected in the hospital from January 2011 to August 2012, who were randomly divided into two groups. 63 patients fasting oral low-dose aspirin （100 mg/time, 1 time/d, course of 4 weeks） in the morning as the control group. 63 patients fasting oral high- dose aspirin （300 mg/time, hime/d, course of 4 weeks） in the morning as the observation group. Clinical indicator, clinical effect, neural function defect score, adverse reaction were compared between two groups. Results After treatment, C reactive protein concentration and neural function defect score in the control group and observation group were significantly decreased. C reactive protein concentration and neural function defect score in the observation group were significantly lower than that of the control group. The difference was statistically significant （P 〈 0.05）. Total effective rate in the observation group （71.4%） was higher than the control group （60.3%）. The incidence of adverse reactions in the observation group （7.9%） was higher than the control group （4.8%）. The differences were not statistically significant （P 〉 0.05）. Conclusion In the treatment of acute cerebral infarction, effect of high-dose aspirin （300 mg/d） is better than the low-dose （100 mg/d ）. Clinical indicators can be improved evidently, and there are no serious adverse reactions. It is worthy of clinical use.

关 键 词：剂量 阿司匹林 急性脑梗死 疗效 

分 类 号：R743[医药卫生—神经病学与精神病学]