尼莫地平和前列地尔治疗脑外伤术后脑血管痉挛的效果比较  

Curative effect comparison between nmodipine and alprostadil for healing post-operative cerebral angio spasm on cerebral trauma

作　　者：薛伟[1] 李永娟[1] 梁俊君[1] 徐晓胜 

机构地区：[1]山东省安丘市人民医院神经外科,山东安丘262100

出　　处：《中国当代医药》2013年第4期92-93,共2页China Modern Medicine

摘　　要：目的探讨尼莫地平和前列地尔治疗脑外伤术后脑血管痉挛的临床效果。方法 64例脑外伤术后患者随机分为对照组及观察组,对照组采用前列地尔预防脑血管痉挛,观察组采用尼莫地平预防脑血管痉挛,比较两组患者颅内主要动脉收缩峰速度及临床治疗效果。结果观察组大脑前动脉、大脑中动脉和大脑后动脉收缩峰速度均显著慢于对照组(P<0.05),观察组痊愈率高于对照组(P<0.05),死亡率低于对照组(P<0.05)。结论尼莫地平能有效预防脑外伤术后颅内血管痉挛,具有较好临床疗效。Obhective To investigate the clinical effect of nmodipine and alprostadil for healing post-operative cere- bral angiospasm on cerebral trauma. Methods Sixty-four cases of patients post-operative cerebral trauma were ran- domly divided into observation group and control group, nmodipine were taken in observation group and alprostadil were taken in control group for healing post-operative cerebral anglo spasm, peak velocity of major cerebral arteries and clinical effect were contrasted between observation group and control group. Results Peak velocity of anterior cerebral artery, middle cerebral artery and posterior cerebral artery was lower in observation group than that in control group （P 〈 0.05）. Cure rate were higher and death rate were lower in observation than that in control group （P 〈 0.05）. Conclusion Nmodipine can effectively prevent post-operative cerebral anglo spasm on cerebral trauma, and has good clinical curative effect.

关 键 词：尼莫地平 前列地尔 脑外伤 脑血管痉挛 

分 类 号：R743[医药卫生—神经病学与精神病学]