自乳化药物传递系统的处方优化方法和应用  

Formulation optimization methods and the application of self-emulsifying drug delivery system

作　　者：吴成杨[1,2] 尹东东[2] 王杏林[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193

出　　处：《中国新药杂志》2013年第2期190-195,共6页Chinese Journal of New Drugs

基　　金：国家重点基础研究发展计划(973计划)课题(2010CB735602;2012CB724002)

摘　　要：目的:综述自乳化药物传递系统的处方优化方法和应用。方法:查阅国内外相关文献进行归纳总结。结果:自乳化药物传递系统的处方优化方法有(伪)三元相图法、正交设计法、响应面优化法、D-优化法、定量构效关系法、高通量处方筛选法等。结论:在自乳化药物传递系统的研究中,可根据考察的因素和指标,选择合适的处方优化方法进行处方优化。Objective： To review the formulation optimization methods and the application of self-emulsif- ying drug delivery system. Methods： The documents published domestically and in foreign were consulted and summarized. Results： Pseudo-ternary phase diagrams, orthogonal design, response surface methodology, D-optimi- zation design, quantitative structure-activity relationship method, and high-throughput formulation screening system were used to optimize the self-emulsifying drug delivery system formulations. Conclusion： According to the investi- gation factors and the evaluation indexes, the right prescription optimization methods could be chosen to optimize the self-emulsifying drug delivery system formulations.

关 键 词：自乳化 药物传递系统 处方优化 

分 类 号：R914.2[医药卫生—药物化学] R944.1[医药卫生—药学]