磁感应热疗联合^(125)I籽源近距离放疗研究  

Feasibility of the Magnetic Induction Hyperthermia Combined with ^(125)I Brachytherapy

作　　者：蔡东阳[1] 李立[2] 孔维超[3] 赵凌云[1] 唐劲天[1] 

机构地区：[1]清华大学粒子技术与辐射成像教育部重点实验室,北京100084 [2]中南大学湘雅医院肿瘤科,长沙410008 [3]北京中医药大学中药学院微生物与生化药学系.北京100102

出　　处：《科技导报》2013年第1期18-22,共5页Science & Technology Review

基　　金：北京市科技计划项目(Z111100067311053)

摘　　要：磁感应热疗植入合金热籽与放射籽源在尺度上处于同一水平,当热籽和放射籽源同时植入肿瘤组织,热场和辐射将共同作用于肿瘤细胞,提高肿瘤细胞的杀灭作用。本文应用电磁学理论计算射频磁场中热籽和放射籽源的产热功率。并将不同分布的热籽和放射籽源置于磁感应设备射频磁场中,调节磁场参数,观察不同条件下的温升曲线。同时研究了放射籽源在磁感应射频磁场下的升温情况以验证放射籽源的安全性,以及合金热籽与放射籽源混合排布情况下的升温情况以验证联合治疗的有效性。理论计算和实验结果表明,放射籽源在磁感应治疗射频磁场下(50～500kHz)磁热效应不显著,其用于热放疗的安全性得到验证。将放射籽源与热籽混合植入琼脂体模和离体肌肉组织,在介质植入区域内温度均远超过43℃,可实现植入区域内热疗对放疗的增敏作用。Both alloy thermo-seed and radiation seed implanted by magnetic induction hyperthermia are at the same level with the scale. When the thermo-seed and radiation seed implant into the tumor tissue at the same time, thermal field and radiation will act together on the tumor cells, enhancing the destruction effect of tumor cell. The electromagnetic theory is applied to calculate the heat production power by thermo-seed and radiation seed in the RF magnetic field; and the thermo-seed and radiation seed are placed with different distributions into the RF magnetic field of the magnetic induction equipment in order to examine the temperature rise curve under various conditions by adjusting the magnetic field parameters. The heating effect of radiation seed in the RF magnetic field are studied in order to verify the safety of the radiation seed; with alloy thermo-seed and radiation seed are in a mixed configuration, the heating effect is studied in order to verify the effectiveness of the combined therapy. The theoretical calculations indicate that the magneto-caloric effect of radiation seed source in the RF magnetic field of magnetic induction therapy （50~500kHz） is insignificant, and the safety of hyperthermia and radiotherapy has been verified. When radiation seed mixing with thermo-seed are implanted into the agar model and the muscle tissue in vitro, the temperature in the media implanted area is far above 43℃, realizing the sensibilization that hyperthermia has on radiotherapy in the implanted-area.

关 键 词：近距离放疗 磁感应热疗 热籽 放射籽源 琼脂体模 

分 类 号：R730.58[医药卫生—肿瘤]